Objective:　To　clarify　the　influence　from　left　ventricular　assist　device　(LVAD)　cannula　anastomosis　on　micro-emboli　movement　by　numerical　simulation　methods.　Methods:　Firstly,　a　patient-specific　aorta　geometric　model　was　reconstructed　based　on　CT　scan　images　of　a　patient　with　heart　failure.　Three　geometric　models　of　LVAD　support　were　established　according　to　clinical　practice,　and　the　outflow　cannula　of　LVAD　was　anastomosed　at　the　three　different　locations　of　ascending　aorta　(the　anterior　wall,　between　anterior　wall　and　lateral　wall,　the　lateral　wall　of　ascending　aorta).　Secondly,　the　computational　fluid　dynamic　(CFD)　approach　combined　with　the　discrete　phase　theory　was　used　to　calculate　the　hemodynamic　states,　and　Fluent　finite　element　software　was　used　for　numerical　simulation　of　the　fluid.　Finally,　the　micro-emboli　distribution　flow　pattern,　wall　shear　stress　(WSS)　and　velocity　vector　were　extracted　to　evaluate　the　hemodynamic　state.　Results:　The　probability　of　micro-emboli　entering　the　brain　vessel　at　the　three　different　anastomosis　locations　were　23.6%,　33.8%　and　36.7%,　respectively.　Besides,　vortex　was　observed　around　the　anastomosis　locations.　Conclusions:　The　different　anastomosis　locations　of　LVAD　cannula　can　significantly　change　the　hemodynamic　environment,　which　will　influence　micro-emboli　movement　in　the　aorta.　The　research　findings　provide　some　insights　and　theoretical　support　for　optimizing　the　anastomosis　to　decrease　occurrence　risk　of　stroke　in　clinic.　Copyright　©　2016　by　the　Editorial　Board　of　Journal　of　Medical　Biomechanics.