AIM:　To　reveal　the　cytokines　involved　in　idiopathic　orbital　inflammatory　disease　(IOID)　and　the　relationship　between　Th17　cells,　IgE　and　IOID　pathogenesis.　METHODS:　Whole　blood　samples　were　processed　immediately　after　collection　and　serological　IgG4,　IgG,　and　IgE　antibodies　were　tested　using　ELISA.　IOID　and　orbital　cavernous　hemangioma　(CH)　tissue　samples　underwent　Bio-Plex　multiplex　cytokine　detection.　Hematoxylin-Eosin　(HE)　staining　of　all　paraffin　samples　suggested　the　histological　features　of　IOIDs,　and　expressions　of　IgG4　and　IL-17A　in　affected　tissues　were　detected　by　immunohistochemistry.　RESULTS:　Among　40　IOID　plasma　samples,　52.5%　(21/40)　were　positive　for　IgG4　and　25%　(10/40)　were　positive　for　IgE.　Overlapped　IgG4　or　IgE　positive　samples　accounted　for　22.5%　(9/40).　Therefore,　IOID　samples　were　separated　into　three　groups.　The　IgE+/IgG4+　group　had　a　relevantly　lower　level　of　pro-inflammatory　cytokine　expression.　IL-4　(Th2　cell　related),　IL-10　and　TGF-beta　1　(Treg　cell　immunity　related)　were　elevated　in　all　three　groups.　Some　of　the　Th17　cell　related　cytokines　(i.e.　IL-17A/F,　IL-25,　IL-23,　and　IL-33)　displayed　higher　expression　levels　in　the　IgE-/IgG4-group　compared　to　the　other　two　groups.　CONCLUSION:　We　discovered　an　IgG4-IgE　co-positive　group　as　well　as　Th17　cell　immune　involvement　in　IgG4-IgE　co-negative　subgtroup　in　IOID　for　the　first　time.　The　pathogenesis　of　IOID　could　differ　from　different　subgroups　according　to　the　IgG4　and　IgE　detection.　Therefore,　we　recommend　that,　Treatment　stratagy　should　be　made　according　to　the　clinical　assessment　of　IgG4-IgE　and　Th17　profile　detection.