A　set　of　propylene-tethered　isatin　dimmers　2a-i　was　synthesized　via　click　chemistry　and　screened　for　their　in　vitro　antimycobacterial　activities　against　Mycobacterium　tuberculosis　(MTB)　H(37)Rv　and　multidrug-resistant　TB.　In　spite　of　all　dimmers　(minimum　inhibitory　concentration:　25-＞128g/mL)　only　exhibited　weak　to　moderate　activities　against　the　tested　MTB　H(37)Rv　and　multidrug-resistant　TB,　the　structure-activity　relationship　was　enriched　and　the　results　warrant　further　development　of　the　anti-TB　properties　of　this　kind　of　dimmers.