As　modern　business　activities　become　increasingly　global,　so　too　does　information　resource　management　(IRM).　To　manage　information　resources　successfully　in　this　global　environment,　one　great　challenge　facing　the　management　team　is　how　to　deal　with　national　cultural　differences.　In　this　chapter,　national　cultural　differences　are　discussed　to　indicate　the　substance　of　IRM　challenges　in　a　cross-cultural　environment.　Many　recently　published　cases　are　studied　to　clarify　management　challenges　of　cross-cultural　ISM.　Primary　management　issues　of　mismatch　between　information　presentation　and　information　procurement　are　analyzed　in　particular　detail.　Further,　management　solutions　oriented　for　IRM　in　a　cross-cultural　environment　are　explored.　Due　to　the　lack　of　similar　research　topics,　this　study　could　supply　a　gap　for　cross-cultural　IRM.　The　contribution　of　this　chapter　will　be　twofold:　one　is　to　set　up　a　sound　management　mechanism　for　cross-cultural　IRM;　the　other　is　to　create　sharable　information　resources　in　a　cross-cultural　environment.　©　2007,　Idea　Group　Inc.