OBJECTIVE:　The　aim　of　the　research　is　to　obtain　the　relative　influences　of　some　critical　electro-thermal　parameters　on　the　ablation　temperature　and　lesion　volume　during　temperature-controlled　radiofrequency　ablation　(RFA)　of　liver　tumor　by　parameter　sensitivity　analysis.　METHODS:　The　finite　element　method　(FEM)　has　been　used　to　establish　the　simulation　model　of　RFA　temperature　field,　and　the　sensitivity　of　the　tissue　parameters　has　been　analyzed.　The　effects　of　six　parameters　have　been　taken　into　account,　including　the　thermal　specific　capacity　(Cp),　the　thermal　conductivity　(k),　the　electrical　conductivity　(Sigma),　the　density　(rho),　the　dielectric　constant　(Epsilon)　and　the　resistance　(R).　The　simulation　processes　based　on　different　parameter　values　have　been　accomplished　with　Comsol　Multiphysics　software,　and　the　sensitivity　parameters　have　been　obtained　utilizing　the　variance　contribution　rate　(SS%)　or　the　main　effects.　RESULTS:　It　was　found　that　the　ablation　temperature　and　lesion　volume　increased　with　increasing　the　values　of　R　and　Sigma,　but　was　a　reverse　situation　for　Cp　and　rho.　Besides,　the　influence　of　k　on　ablation　volume　was　relatively　small　and　Epsilon　had　a　negligible　effect　on　ablation　temperature.　CONCLUSIONS:　It　is　concluded　that　these　parameter　sensitivity　results　can　provide　scientific　and　reliable　reference　for　the　specificity　analysis　of　the　RF　ablation　models.