Study on the DNA damage induced by peroxynitrite and its inhibitors - 文章详情页

作者：

Luo, Y. (Luo, Y..) | Li, Y. (Li, Y..) | Liu, L. (Liu, L..) | Zhong, R. (Zhong, R..)

收录：

Scopus PKU CSCD

摘要：

Peroxynitrite,　which　is　cytotoxic,　can　modify　DNA　bases　and　make　DNA　single　strand　breaks.　In　this　paper,　the　reaction　of　DNA　and　peroxynitrite　was　studied　through　HPLC-ECD　and　agarose　electrophoresis.　The　results　showed　that　the　deoxyguanosine　modification　and　DNA　strand　breaks　upon　the　concentration　of　peroxynitrite.　Then　inhibitory　effects　of　some　crude　inhibitors,　such　as　quercetin,　flavone,　α-naphthoflavone,　caffeic　acid,　L-gluathione,　lipoic　acid　on　DNA　damages　was　investigated,　too.　The　results　indicated　the　inhibitory　effects　of　quercetin　and　caffeic　acid　were　more　effectively　than　that　of　flavone　and　α-naphylflavone;　and　the　DNA　damages　can　be　inhibited　by　the　compounds　containing　-　SH　group　(e.g.　L-glutathione,　lipoic　acid).

关键词：

8-hydroxydeoxyguanosine; DNA strand breaks; Flavonoids; Inhibitors; Peroxynitrite

作者机构：

[ 1 ] [Luo, Y.]College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100022, China
[ 2 ] [Li, Y.]College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100022, China
[ 3 ] [Liu, L.]College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100022, China
[ 4 ] [Zhong, R.]College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100022, China

通讯作者信息：

[Luo, Y.]College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100022, China

电子邮件地址：

luoyj@bjut.edu.cn

查看成果更多字段

成果类型
所属机构

所有年份指定年份从至