Diethylstilbestrol　(DES)　is　considered　a　representative　example　of　an　exogenous　endocrine　disrupting　compound　(EDC).　It　can　retard　development　in　infants,　lead　to　serious　metabolic　regulation　disorders,　and　even　result　in　distortion　and　cancer　in　the　reproductive　system.　Therefore,　achieving　rapid　and　accurate　analysis　of　trace　amounts　of　DES　in　complex　environments　is　of　great　importance　to　human　health　and　for　environmental　protection.　Novel　magnetic　molecularly　imprinted　polymers　(MIPs)　with　excellent　molecular　recognition　ability　and　super　water-compatibility　were　developed　for　the　selective　capture　of　DES　in　water　samples.　Fe3O4@SiO2　magnetic　nanoparticles　(NPs)　were　synthesized　and　used　as　support　cores.　Molecularly　imprinted　poly(3-aminophenylboronic　acid)　(poly(APBA)),　synthesized　on　magnetic　cores　based　on　a　surface-imprinting　strategy,　can　preferentially　bind　DES　molecules　in　water　samples.　The　magnetic　core-shell　MIPs　(denoted　as　Fe3O4@SiO2@APBA/MIPs)　exhibited　high　binding　capacity　and　favorable　recognition　specificity　for　DES　in　water.　The　adsorption　kinetics　and　experimental　isotherm　data　of　DES　on　magnetic　MIPs　can　be　well　described　by　the　pseudo-second-order　kinetic　model　and　the　Langmuir　isotherm,　respectively.　The　imprinted　nanoparticles　were　subjected　to　magnetic　solid-phase　extraction　(MSPE)　of　DES　from　water　samples.　The　DES　content　in　the　samples　was　determined　by　high-performance　liquid　chromatography　(HPLC).　The　peak　area　increased　linearly　with　increasing　DES　concentration　over　the　range　0.08-150　g　L-1,　with　a　detection　limit　of　0.03　g　L-1.　The　recoveries　for　spiked　lake　water　samples　were　in　the　range　97.1-103.2%,　with　relative　standard　deviation　(RSD)　of　2.8-4.3%　(n　=　6).