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作者:

Huang, Xin (Huang, Xin.) | Li, Zhipeng (Li, Zhipeng.) | Cao, Tingting (Cao, Tingting.) | Cai, Qian (Cai, Qian.) | Zeng, Chengchu (Zeng, Chengchu.) (学者:曾程初) | Fu, Hua (Fu, Hua.) | Hu, Liming (Hu, Liming.) (学者:胡利明)

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摘要:

A methylene blue-based near-infrared fluorescent probe was designed for the selective determination of hypochlorite (ClO-), over other reactive oxygen species or interfering agents. Acetylated methylene blue was synthesized by introducing the acetyl group into the methylene blue framework, which can specifically recognize exogenous and endogenous ClO-. The acetylated methylene blue fluorescent probe was characterized by H-1 NMR, C-13 NMR and HRMS. The response process and possible mechanism were studied using products of the probe. The emission response of the probe to ClO- presented good linear relationship in the 0-60 M concentration range, with the detection limit of 0.1 M (measured at 660 nm and 690 nm). The absorption and emission wavelengths of acetylated methylene blue are both in the near-infrared region; in addition, the probe itself and the degradation products were well-dissolved in water and have almost no toxicity. The probe was used for intracellular ClO- imaging and showed a large fluorescence enhancement (about 200-fold increase).

关键词:

作者机构:

  • [ 1 ] [Huang, Xin]Beijing Univ Technol, Beijing Key Lab Environm & Oncol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China
  • [ 2 ] [Li, Zhipeng]Beijing Univ Technol, Beijing Key Lab Environm & Oncol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China
  • [ 3 ] [Cao, Tingting]Beijing Univ Technol, Beijing Key Lab Environm & Oncol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China
  • [ 4 ] [Cai, Qian]Beijing Univ Technol, Beijing Key Lab Environm & Oncol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China
  • [ 5 ] [Zeng, Chengchu]Beijing Univ Technol, Beijing Key Lab Environm & Oncol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China
  • [ 6 ] [Hu, Liming]Beijing Univ Technol, Beijing Key Lab Environm & Oncol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China
  • [ 7 ] [Fu, Hua]Tsinghua Univ, Minist Educ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China
  • [ 8 ] [Hu, Liming]Tsinghua Univ, Minist Educ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China

通讯作者信息:

  • 胡利明

    [Hu, Liming]Beijing Univ Technol, Beijing Key Lab Environm & Oncol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China;;[Hu, Liming]Tsinghua Univ, Minist Educ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China

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来源 :

RSC ADVANCES

ISSN: 2046-2069

年份: 2018

期: 26

卷: 8

页码: 14603-14608

3 . 9 0 0

JCR@2022

ESI学科: CHEMISTRY;

ESI高被引阀值:192

被引次数:

WoS核心集被引频次: 20

SCOPUS被引频次: 18

ESI高被引论文在榜: 0 展开所有

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