This　study　focused　on　the　changes　of　network　topological　efficiency　under　the　condition　of　maximizing　the　intrinsic　functional　connectivity,　and　explored　the　relationships　between　altered　topological　efficiency　and　depressive　psychopathology.　For　this　purpose,　we　collected　the　resting-state　functional　MRI　data　from　20　major　depressive　disorder　(MDD)　patients　and　20　healthy　control　(HC)　individuals　with　matching　of　age,　gender　and　education　level.　Graph　theory　analysis　showed　that　the　patients　with　MDD　exhibited　significantly　reduced　nodal　efficiency　in　the　left　parahippocampal　gyms,　right　amygdala,　left　heschl　and　left　temporal　pole　(middle　temporal　gyrus)　compared　with　the　HC　group.　The　reduced　nodal　efficiency　indicated　that　the　function　of　transmitting　information　to　other　regions　was　weakened　in　MDD　patients.　The　local　efficiency　of　the　left　medial　superior　frontal　gyrus,　left　orbital　superior　frontal　gyrus,　right　rectus,　left　amygdala,　right　superior　parietal　gyrus,　left　thalamus,　and　left　temporal　pole　(middle　temporal　gyrus)　were　also　significantly　reduced.　And　the　local　efficiency　of　the　left　medial　superior　frontal　gyrus,　left　amygdala,　left　thalamus　had　negative　correlation　with　PHQ-9.　The　reduced　local　efficiency　implied　that　the　ability　of　information　transmission　at　the　local　level　was　damaged　in　the　depressed　brain　network.　These　results　suggested　that　the　prefrontal-thalamo-limbic　system　involving　affective　processing　was　damaged　in　MDD　patients.　Our　findings　might　provide　a　potential　biomarker　for　the　clinical　diagnosis　of　depressed　patients.