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作者:

Liang, Bin (Liang, Bin.) | Li, Yongbao (Li, Yongbao.) | Wei, Ran (Wei, Ran.) | Guo, Bin (Guo, Bin.) | Xu, Xuang (Xu, Xuang.) | Liu, Bo (Liu, Bo.) (学者:刘博) | Li, Jiafeng (Li, Jiafeng.) | Wu, Qiuwen (Wu, Qiuwen.) | Zhou, Fugen (Zhou, Fugen.)

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EI Scopus SCIE

摘要:

With robot-controlled linac positioning, robotic radiotherapy systems such as CyberKnife significantly increase freedom of radiation beam placement, but also impose more challenges on treatment plan optimization. The resampling mechanism in the vendor-supplied treatment planning system (MultiPlan) cannot fully explore the increased beam direction search space. Besides, a sparse treatment plan (using fewer beams) is desired to improve treatment efficiency. This study proposes a singular value decomposition linear programming (SVDLP) optimization technique for circular collimator based robotic radiotherapy. The SVDLP approach initializes the input beams by simulating the process of covering the entire target volume with equivalent beam tapers. The requirements on dosimetry distribution are modeled as hard and soft constraints, and the sparsity of the treatment plan is achieved by compressive sensing. The proposed linear programming (LP) model optimizes beam weights by minimizing the deviation of soft constraints subject to hard constraints, with a constraint on the l(1) norm of the beam weight. A singular value decomposition (SVD) based acceleration technique was developed for the LP model. Based on the degeneracy of the influence matrix, the model is first compressed into lower dimension for optimization, and then back-projected to reconstruct the beam weight. After beam weight optimization, the number of beams is reduced by removing the beams with low weight, and optimizing the weights of the remaining beams using the same model. This beam reduction technique is further validated by a mixed integer programming (MIP) model. The SVDLP approach was tested on a lung case. The results demonstrate that the SVD acceleration technique speeds up the optimization by a factor of 4.8. Furthermore, the beam reduction achieves a similar plan quality to the globally optimal plan obtained by the MIP model, but is one to two orders of magnitude faster. Furthermore, the SVDLP approach is tested and compared with MultiPlan on three clinical cases of varying complexities. In general, the plans generated by the SVDLP achieve steeper dose gradient, better conformity and less damage to normal tissues. In conclusion, the SVDLP approach effectively improves the quality of treatment plan due to the use of the complete beam search space. This challenging optimization problem with the complete beam search space is effectively handled by the proposed SVD acceleration.

关键词:

compressive sensing CyberKnife system linear programming radiotherapy optimization SVD

作者机构:

  • [ 1 ] [Liang, Bin]Beihang Univ, Image Proc Ctr, Beijing 100191, Peoples R China
  • [ 2 ] [Li, Yongbao]Beihang Univ, Image Proc Ctr, Beijing 100191, Peoples R China
  • [ 3 ] [Wei, Ran]Beihang Univ, Image Proc Ctr, Beijing 100191, Peoples R China
  • [ 4 ] [Guo, Bin]Beihang Univ, Image Proc Ctr, Beijing 100191, Peoples R China
  • [ 5 ] [Xu, Xuang]Beihang Univ, Image Proc Ctr, Beijing 100191, Peoples R China
  • [ 6 ] [Liu, Bo]Beihang Univ, Image Proc Ctr, Beijing 100191, Peoples R China
  • [ 7 ] [Zhou, Fugen]Beihang Univ, Image Proc Ctr, Beijing 100191, Peoples R China
  • [ 8 ] [Liang, Bin]Chinese Acad Med Sci, Canc Hosp, Natl Canc Ctr, Dept Radiat Oncol, Beijing 100021, Peoples R China
  • [ 9 ] [Liang, Bin]Peking Union Med Coll, Beijing 100021, Peoples R China
  • [ 10 ] [Li, Jiafeng]Beijing Univ Technol, Signal & Informat Proc Lab, Beijing 100124, Peoples R China
  • [ 11 ] [Wu, Qiuwen]Duke Univ, Med Ctr, Dept Radiat Oncol, Durham, NC 27710 USA

通讯作者信息:

  • 刘博

    [Liu, Bo]Beihang Univ, Image Proc Ctr, Beijing 100191, Peoples R China

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来源 :

PHYSICS IN MEDICINE AND BIOLOGY

ISSN: 0031-9155

年份: 2018

期: 1

卷: 63

3 . 5 0 0

JCR@2022

ESI学科: MOLECULAR BIOLOGY & GENETICS;

ESI高被引阀值:152

被引次数:

WoS核心集被引频次: 2

SCOPUS被引频次: 2

ESI高被引论文在榜: 0 展开所有

万方被引频次:

中文被引频次:

近30日浏览量: 2

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在线人数/总访问数:2017/2982995
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