In　the　face　of　serious　environmental　pollution　and　water　scarcity　problems,　the　membrane　separation　technique,　especially　high　efficiency,　low　energy　consumption,　and　environmental　friendly　nanofiltration,　has　been　quickly　developed.　Separation　membranes　with　high　permeability,　good　selectivity,　and　strong　antifouling　properties　are　critical　for　water　treatment　and　green　chemical　processing.　In　recent　years,　researchers　have　paid　more　and　more　attention　to　the　development　of　high　performance　nanofiltration　membranes　containing　ion　pairs.　In　this　review,　the　effects　of　ion　pairs　characteristics,　such　as　the　super-hydrophilicity,　controllable　charge　character,　and　antifouling　property,　on　nanofiltration　performances　are　discussed.　A　systematic　survey　was　carried　out　on　the　various　approaches　and　multiple　regulation　factors　in　the　fabrication　of　polyelectrolyte　complex　membranes,　zwitterionic　membranes,　and　charged　mosaic　membranes,　respectively.　The　mass　transport　behavior　and　antifouling　mechanism　of　the　membranes　with　ion　pairs　are　also　discussed.　Finally,　we　present　a　brief　perspective　on　the　future　development　of　advanced　nanofiltration　membranes　with　ion　pairs.