To　explore　the　significance　of　human　papilloma　virus　type　52　(HPV52)　infection　and　its　integration　in　cells　within　cervical　lesions,　the　expression　levels　of　HPV52　were　detected　using　polymerase　chain　reaction　(PCR).　The　copy　numbers　of　HPV52　E2,　HPV52　E6　and　the　reference　gene　beta-actin　were　determined　by　quantitative　PCR　to　analyze　the　association　between　HPV52　integration　and　cervical　lesions.　HPV52　integration　was　analyzed　by　the　amplification　of　papillomavirus　oncogene　transcripts.　A　total　of　13　samples　from　468　cases　were　positive　for　HPV52.　Among　the　samples,　1　case　with　an　E2/E6　ratio　＞1　was　purely　episomal,　3　cases　with　an　E2/E6　ratio　of　0　were　purely　integrated,　and　9　cases　with　an　E2/E6　ratio　of　between　0　and　1　were　a　mixture　of　integrated　and　episomal.　With　the　progression　of　cervical　disease,　the　prevalence　of　the　episomal　type　decreased　gradually,　and　the　prevalence　of　the　integrated　(episomal　and　integrated)　forms　increased.　The　pure　integration　of　HPV52　occurred　in　chromosomes　2,　5　and　8.　These　results　indicate　that　HPV52　integration　into　the　host　genome　may　be　a　key　factor　in　cervical　lesions.　Thus,　patients　at　high　risk　for　cervical　lesions　may　potentially　be　identified　by　screening　for　HPV52　infection　and　integration.