Transportation　has　a　profound　influence　on　the　regional　development　system,　and　two　systems　in　the　interaction　process　often　occur　many　disharmonious　phenomena.　Accessibility　is　an　important　indicator　to　measure　the　effectiveness　of　transportation　network　system,　the　further　development　of　accessibility　can　effectively　promote　regional　economic.　Highway　network　construction　can　further　optimize　the　regional　road　network　and　promote　accessibility,　so　as　to　further　improve　the　coordinated　development　of　regional　economy.　In　this　paper,　through　the　grey　correlation　and　the　evolution　analyses　of　the　relative　accessibility　of　highway　network　in　Hubei　Province,　the　further　changes　in　accessibility　Association　for　regional　development　were　studied　and　the　related　classification　comparison　was　done.　Finally,　we　put　forward　suggestions　to　promote　the　coordinated　development　of　transportation　and　regional　development.