A　kind　of　organic-inorganic　hybrid　composite　with　core-shell　structure　was　successfully　prepared　via　seed　polymerization　method　using　environmental　stimuli　(pH/temperature)　copolymer　poly(N-isopropylacryl-acrylamide)-co-poly(acrylic　acid)　(P(NIPAM-co-AA))　as　a　shell　and　bimodal　mesoporous　silica　nanoparticles　(BMMs)　with　small　size　of　20-50　nm　as　a　core.　The　capacity　of　loading　ibuprofen　(IBU)　and　the　subsequent　release　performance　from　resultant　P(NIPAM-co-AA)@BMMs　(denoted　as　P@BMMs)　under　different　external　conditions　were　investigated　in　detail.　Meanwhile,　its　structural　features　and　textural　parameters　were　characterized　using　XRD,　N-2　adsorption-desorption　isotherms,　SEM　and　TEM,　SAXS,　FT-IR,　solid-state　Si-29　NMR,　TGA　and　elemental　analysis　techniques.　The　results　demonstrated　that　P(NIPAM-co-AA)　as　a　shell　coating　on　the　external　surface　of　BMMs　acted　as　temperature-pH　gate　valve　to　control　release　behaviors,　while　mesoporous　BMMs　as　reservoir　provided　enough　space　to　encapsulate　IBU　molecules　with　high　loading.　SAXS　patterns　evidently　presented　that　P@BMMs　before　IBU-loading　and　after　releasing　possessed　the　fractal　feature,　suggesting　their　surface　roughness　and　structural　irregularities,　in　which　the　mass　fractal　was　increased　from　2.36　for　BMMs　to　2.41　for　BMMs-MPS　to　2.51　for　P@BMMs,　and　even　the　transformation　from　the　mass　fractal　to　surface　fractal　for　I/P@BMMs　was　about　2.80.　In　addition,　three　types　of　kinetic　models　(first-order,　Higuchi　and　Koismeyer-Peppas　power　law)　were　employed　to　evaluate　the　release　profiles,　indicating　that　the　drug　release　kinetic　of　P@BMMs　was　suitable　to　Korsmeyer-Peppas　power　law　model　with　non-Fickian　diffusion　mechanism.　(C)　2017　Elsevier　Inc.　All　rights　reserved.