For　cooling　specific　chip　of　2　mm*10　mm,　the　4-ports　and　offset　zigzag　microchannels　are　designed.　The　fluid　flow　and　heat　transfer　characteristics　of　4-ports　silicon　heat　sinks　with　rectangle　and　zigzag　microchannels　have　been　investigated　experimentally.　Deionized　water　is　employed　as　the　cooling　fluid　with　flow　rates　of　28-72　ml/min.　Results　show　the　4-ports　heat　sink　can　effectively　reduce　pressure　drops　and　reduce　temperature　rising　along　the　flow　directions　for　the　fixed　flow　rates.　For　4-ports　with　rectangle　microchannel,　the　pressure　drops　is　decreased　about　70%　and　average　temperature　also　is　reduced　by　2.8　degrees　C.　It　can　be　interpreted　that　4-ports　structures　reduce　the　length　of　channel　and　increase　channel　number,　which　leads　to　the　flow　velocity　decreased　by　0.5　times　and　the　fluid　distribution　more　uniform.　Compared　with　4-ports　with　rectangle　microchannels,　for　4-ports　with　zigzag　microchannels　heat　sink,　the　pressure　drop　is　reduced　under　the　lower　flow　rates　but　increased　slightly　under　larger　flow　rates.　And　temperatures　of　all　flow　rates　are　reduced,　which　is　reduced　by　3.8　degrees　C　and　pressure　drop　only　increased　2.6　kPa　at　flow　rates　of　72　ml/min.　It　can　be　interpreted　that　zigzag　cavities　redevelop　thermal　boundary　layer　and　enhance　the　fluid　disturbance　to　make　the　fluid　mixing　better.　Additional,　zigzag　cavities　also　enlarge　heat　transfer　areas　and　reduce　the　fluid　velocity　by　increasing　flow　cross-section　areas.　Under　fixed　pumping　power,　4-ports　with　Z　can　meet　the　larger　heat　dissipation　and　smaller　flow　rates　requirement.