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作者:

Wu, Guanghui (Wu, Guanghui.) | Xu, Chuangye (Xu, Chuangye.) | Liu, Xiujian (Liu, Xiujian.) | Lin, Changyan (Lin, Changyan.) | Yang, Lin (Yang, Lin.) | Li, Haiyang (Li, Haiyang.) | Hou, Xiaotong (Hou, Xiaotong.) | Chen, Chen (Chen, Chen.) | Yang, Peng (Yang, Peng.)

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CPCI-S Scopus SCIE

摘要:

A small implantable centrifugal left ventricular assist device, the CH-VAD (CH Biomedical Inc, JiangSu, China), featuring a magnetically levitated impeller is under development. The goal of this study is to validate hydrodynamic performance and hemocompatibility of the pump through in vitro studies. The hydraulic performance was quantified experimentally by using in vitro circulation loop system, and it turned out that the pump could deliver 5 L/min under a pressure of 100 mmHg at a rotational speed of approximate 3400 rpm. A series of in vitro tests were established according to ASTM F1841, the standard practice for the assessment of hemolysis in continuous-flow blood pumps. The results showed that the average normalized index of hemolysis (NIH) value of the VAD was 0.0007 +/- 0.0003 mg/dL. The magnetic levitation left ventricular assist device (LVAD) has good hemolytic performance and stable mechanical property. These acceptable performance results supported proceeding initial acute animal testing conditions.

关键词:

magnetic levitation hemolysis test in vitro Left ventricular assist device (LVAD) normalized index of hemolysis (NIH)

作者机构:

  • [ 1 ] [Wu, Guanghui]Capital Med Univ, Beijing Anzhen Hosp, Beijing Inst Heart Lung & Blood Vessel Dis, AnZhen Str 2, Beijing 100029, Peoples R China
  • [ 2 ] [Xu, Chuangye]Capital Med Univ, Beijing Anzhen Hosp, Beijing Inst Heart Lung & Blood Vessel Dis, AnZhen Str 2, Beijing 100029, Peoples R China
  • [ 3 ] [Liu, Xiujian]Capital Med Univ, Beijing Anzhen Hosp, Beijing Inst Heart Lung & Blood Vessel Dis, AnZhen Str 2, Beijing 100029, Peoples R China
  • [ 4 ] [Lin, Changyan]Capital Med Univ, Beijing Anzhen Hosp, Beijing Inst Heart Lung & Blood Vessel Dis, AnZhen Str 2, Beijing 100029, Peoples R China
  • [ 5 ] [Yang, Lin]Beijing Univ Technol, Coll Life Sci & Bioengn, PingLeYuan Str 100, Beijing 100029, Peoples R China
  • [ 6 ] [Li, Haiyang]Capital Med Univ, Beijing Anzhen Hosp, AnZhen Str 2, Beijing 100029, Peoples R China
  • [ 7 ] [Hou, Xiaotong]Capital Med Univ, Beijing Anzhen Hosp, AnZhen Str 2, Beijing 100029, Peoples R China
  • [ 8 ] [Chen, Chen]CH Biomed Inc, Suzhou Ind Pk,East Bldg 2-6,Room 202, Nanjing 215125, Jiangsu, Peoples R China
  • [ 9 ] [Yang, Peng]CH Biomed Inc, Suzhou Ind Pk,East Bldg 2-6,Room 202, Nanjing 215125, Jiangsu, Peoples R China

通讯作者信息:

  • [Lin, Changyan]Capital Med Univ, Beijing Anzhen Hosp, Beijing Inst Heart Lung & Blood Vessel Dis, AnZhen Str 2, Beijing 100029, Peoples R China;;[Yang, Lin]Beijing Univ Technol, Coll Life Sci & Bioengn, PingLeYuan Str 100, Beijing 100029, Peoples R China

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来源 :

JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY

ISSN: 0219-5194

年份: 2017

期: 7

卷: 17

0 . 8 0 0

JCR@2022

ESI学科: MOLECULAR BIOLOGY & GENETICS;

ESI高被引阀值:309

中科院分区:4

被引次数:

WoS核心集被引频次: 1

SCOPUS被引频次: 1

ESI高被引论文在榜: 0 展开所有

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