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作者:

Guo, C. (Guo, C..) | Ahmed, S. (Ahmed, S..) | Liu, X. (Liu, X..) (学者:刘晓)

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Scopus

摘要:

Solid tumors are heterogeneous in composition. Cancer stem cells (CSCs) are a highly tumorigenic cell type found in developmentally diverse tumors that are believed to be resistant to standard chemotherapeutic drugs and responsible for tumor recurrence. Thus understanding the tumor growth kinetics is critical for development of novel strategies for cancer treatment. In this paper, the moment stability of nonlinear stochastic systems of breast cancer stem cells with time-delays has been investigated. First, based on the technique of the variation-of-constants formula, we obtain the second order moment equations for the nonlinear stochastic systems of breast cancer stem cells with time-delays. By the comparison principle along with the established moment equations, we can get the comparative systems of the nonlinear sto-chastic systems of breast cancer stem cells with time-delays. Then moment stability theorems have been established for the systems with the stability properties for the comparative systems. Based on the linear matrix inequality (LMI) technique, we next obtain a criteria for the exponential stability in mean square of the nonlinear stochastic systems for the dynamics of breast cancer stem cells with time-delays. Finally, some numerical examples are presented to illustrate the efficiency of the results.

关键词:

Breast Cancer Stem Cells; Comparison Principle; Linear Matrix Inequality (LMI).; Mean Square Stability; Moment Stability; Stochastic Systems

作者机构:

  • [ 1 ] [Guo, C.]School of Applied Mathematics, Guangdong University of Technology, Guangzhou, 510006, China
  • [ 2 ] [Guo, C.]Center of Clinical Pharmacology, Third Xiangya Hospital, Central South University, Changsha, 410083, China
  • [ 3 ] [Ahmed, S.]Department of Mathematics, University of South Carolina, Columbia, SC 29208, United States
  • [ 4 ] [Liu, X.]Department of Mathematics, University of South Carolina, Columbia, SC 29208, United States
  • [ 5 ] [Liu, X.]Beijing Center for Scientific and Engineering Computing, Beijing University of Technology, Beijing, 100124, China

通讯作者信息:

  • [Ahmed, S.]Department of Mathematics, University of South CarolinaUnited States

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来源 :

Discrete and Continuous Dynamical Systems - Series B

ISSN: 1531-3492

年份: 2016

期: 8

卷: 21

页码: 2473-2489

1 . 2 0 0

JCR@2022

ESI学科: MATHEMATICS;

ESI高被引阀值:45

中科院分区:3

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WoS核心集被引频次: 0

SCOPUS被引频次: 4

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