Antifouling　performance　of　nanofiltration　membrane　is　critical　in　applications　like　water　treatment.　In　this　study,　surface　zwitterionization　was　conducted　by　1,　3-propanesultone　ring-opening　directly　on　the　nanofiltration　membrane　prepared　by　interfacial　polymerization　of　3,3＇-diamino-N-methyldipropylamine　and　1,　3,　5　benzenetricarboxylic　chloride.　The　zwitterionic　structures　improve　the　hydrophilicity　of　nanofiltration　membrane,　thus　increase　the　water　permeability　and　antifouling　performance.　The　zwitterionic　membrane　have　a　72　L　m(-2)　h(-1)　water　flux　at　the　optimize　condition,　which　was　about　2.4　times　that　of　the　pristine　membrane　without　zwitterionization,　and　with　a　89%　rejection　of　MgCl2.　Meanwhile,　the　zwitterionic　membrane　will　have　better　antifouling　performance　to　protein　and　polysaccharose.　The　flux　recovery　ratio　of　bovine　serum　albumin,　sodium　alginate　and　lysozyme　were　all　above　95%.　The　prepared　zwitterionic　membrane　presents　prominent　high　water　flux　and　fouling-resistance　performance,　indicating　it＇s　promising　application　potential　in　organic　wastewater　treatment.