Biodegradable　magnesium　(Mg)　alloy　emerges　as　revolutionary　biomaterial　by　meeting　both　engineering　and　medical　requirements　for　implants.　In　this　study,　we　report　a　Mg　alloy　Mg-2.5Nd-0.21Zn-0.44Zr　(wt.　%,　denoted　as　JDBM)　potential　for　vascular　stent　application　due　to　its　outstanding　performance　in　corrosion　behaviors　and　biocompatibility.　The　investigation　of　corrosion　properties　evaluated　by　immersion　test　and　electrochemical　measurement　shows　less　susceptibility　to　pitting　corrosion　and　lower　corrosion　rate　of　JDBM　as　compared　with　AZ31　alloy.　The　corrosion　products　of　JDBM　do　not　cause　significant　adverse　effect　on　the　cell　viability　and　growth　during　in　vitro　cytotoxicity　test　of　the　Mg　extract　via　human　vascular　endothelial　cells　(HUVECs).　We　also　investigated　macrophage　response　to　the　Mg　extract　and　observed　compromised　foreign　body　reaction　(FBR)　determined　by　human　peripheral　blood　derived　macrophage　fusion　and　inflammatory　cytokine　and　chemokine　secretion.　At　last,　we　performed　in　vivo　degradation　assessment　via　implantation　of　JDBM　stent　in　an　animal　model,　and　confirmed　long-term　stability　and　structural　integrity　of　the　stent　in　blood　vessel.　Thus,　the　JDBM　alloy　with　excellent　biocompatibility　and　long-term　stability　and　durability　in　vivo,　represents　a　significant　advance　in　the　development　of　biodegradable　implants.　(C)　2017　Elsevier　B.V.　All　rights　reserved.