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Author:

Jin, Cong (Jin, Cong.) | Chao, Yi-Ping (Chao, Yi-Ping.) | Lin, Lan (Lin, Lan.) | Fu, Zhenrong (Fu, Zhenrong.) | Zhang, Baiwen (Zhang, Baiwen.) | Wu, Shuicai (Wu, Shuicai.) (Scholars:吴水才)

Indexed by:

EI Scopus SCIE

Abstract:

Hubs are a set of highly connected brain regions which play an important role in the human brain network. Various graph measurements and parcellation atlases have been utilized for hub identification. However, the relationship of those measurements and the comparison of hub identification results derived from different types of brain networks are not clear yet. The current study used four measurements to identify hubs in 75 healthy aging subjects' brain networks. Also, to figure out the potential effect using various parcellation schemes on the hub identification, five kinds of brain networks were constructed, which were accomplished by two types of brain parcellation schemes including anatomical parcellation atlases (AAL atlas and HOA altas) and random parcellation scheme (uniformed parcellation atlas with 32, 128 and 512 regions). From the results, we found that hubs can be consistently identified in the same type of brain network regardless of measurements. On the contrary, hubs were notably different in the different types of brain networks even using the same measurement. Beyond these, hub consistency between measurements derived from anatomical brain networks tend to be relatively stable than that derived from uniformed parcellated brain networks. Importantly, the consistency of identification results of uniformed parcellated brain networks were also constrained by the selection of identification threshold level. For the relationship between graph measurements, results revealed a robust relationship between vulnerability and other measurements. Our findings provide a better understanding to the effect of identification measurements, parcellation atlases, and identification thresholds on the hub identification, which may offer a future prospect of being able to create a unified standard for the hub identification.

Keyword:

Graph measurements Brain network Hub regions Diffusion tensor imaging (DTI)

Author Community:

  • [ 1 ] [Jin, Cong]Beijing Univ Technol, Coll Life Sci & Bioengn, Biomed Res Ctr, 100 Ping Le Yuan, Beijing 100124, Peoples R China
  • [ 2 ] [Lin, Lan]Beijing Univ Technol, Coll Life Sci & Bioengn, Biomed Res Ctr, 100 Ping Le Yuan, Beijing 100124, Peoples R China
  • [ 3 ] [Fu, Zhenrong]Beijing Univ Technol, Coll Life Sci & Bioengn, Biomed Res Ctr, 100 Ping Le Yuan, Beijing 100124, Peoples R China
  • [ 4 ] [Zhang, Baiwen]Beijing Univ Technol, Coll Life Sci & Bioengn, Biomed Res Ctr, 100 Ping Le Yuan, Beijing 100124, Peoples R China
  • [ 5 ] [Wu, Shuicai]Beijing Univ Technol, Coll Life Sci & Bioengn, Biomed Res Ctr, 100 Ping Le Yuan, Beijing 100124, Peoples R China
  • [ 6 ] [Chao, Yi-Ping]Chang Gung Univ, Dept Comp Sci & Informat Engn, Taoyuan 33302, Taiwan
  • [ 7 ] [Chao, Yi-Ping]Chang Gung Univ, Hlth Aging Res Ctr, Taoyuan 33302, Taiwan
  • [ 8 ] [Chao, Yi-Ping]Chang Gung Mem Hosp Linkou, Dept Neurol, Taoyuan 33305, Taiwan

Reprint Author's Address:

  • [Lin, Lan]Beijing Univ Technol, Coll Life Sci & Bioengn, Biomed Res Ctr, 100 Ping Le Yuan, Beijing 100124, Peoples R China

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Source :

JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING

ISSN: 1609-0985

Year: 2017

Issue: 5

Volume: 37

Page: 653-665

2 . 0 0 0

JCR@2022

ESI Discipline: MOLECULAR BIOLOGY & GENETICS;

ESI HC Threshold:309

CAS Journal Grade:4

Cited Count:

WoS CC Cited Count: 1

SCOPUS Cited Count: 5

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 1

Online/Total:534/5284136
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