A　resilient　prestressed　steel　frame　system　with　intermediate　columns　containing　friction　dampers　(ICRPSF)　has　been　proposed　for　the　use　in　a　large　span,　seismically　active　regions　and　a　high-value　building.　Seismic　performance　analysis　of　overall　structure　of　a　resilient　prestressed　steel　frame　with　intermediate　column　friction　damper　are　analyzed,　compared　with　the　resilient　performance　of　a　resilient　prestressed　steel　frame　(RPSF)　with　beam　web　friction　damper.　The　results　show　that　an　ICRPSF　effectively　controls　the　story　drift,　dissipates　more　energy　through　the　intermediate　column　friction　damper　(ICFD)　and　curbs　the　plastic　development　of　the　component.　This　system　has　a　small　post-seismic　residual　story　drift　and　its　structure　demonstrates　excellent　self-centering　capability.