A　reversed-phase　high-performance　liquid　chromatography　(RP-HPLC)　method　was　developed　and　validated　for　determination　of　ibuprofen　and　17　related　compounds　(chemical　process　impurities　and　degradation　products)　simultaneously.　This　method　may　be　used　for　quality　control　of　ibuprofen-containing　substances.　A　number　of　chromatographic　parameters　(column,　flow　rate,　temperature,　wavelength,　gradient　elution,　buffer　solution,　and　pH)　were　evaluated.　An　Agilent　ZORBAX　Eclipse　Plus　C18　(250　x　4.6　mm,　5　mu　m　particle　size)　column　at　40　A　degrees　C　was　selected　on　the　basis　of　its　separation　efficiency　and　robustness.　The　column　was　eluted　at　1.0　mL　min(-1)　with　a　gradient　using　10　mM　sodium　phosphate　buffer　at　pH　6.9　as　mobile　phase　A　and　acetonitrile　as　mobile　phase　B.　The　ultraviolet　detector　was　set　at　214　nm.　This　method　was　validated　to　confirm　its　system　suitability,　specificity,　linearity,　precision,　accuracy,　sensitivity,　robustness,　and　sample　stability　according　to　international　conference　on　harmonization　(ICH)　guidelines.　This　method　was　applied　to　analyze　seven　batches　of　ibuprofen　drug　products　from　different　manufacturers.