Copper(II)-paddlewheel-based　metal-organic　frameworks　(CP-MOFs)　represent　a　unique　subclass　of　MOFs　with　highly　predictable　porous　structures,　facile　syntheses,　and　functional　open　metal　sites.　However,　the　lack　of　high　hydrolytic　stability　is　an　obstacle　for　CP-MOFs　in　many　practical　applications.　In　this　work,　we　report　a　new　CP-MOF,　[Cu-4(tdhb)]　(BUT-155),　which　is　constructed　from　a　judiciously　designed　carboxylate　ligand　with　high　coordination　connectivity　(octatopic),　abundant　hydrophobic　substituents　(six　methyl　groups),　and　substituent　constrained　geometry　(tetrahedral　backbone),　tdhb(8-)　[H(8)tdhb　=　3,3＇,5,5＇-tetralcis　(3,5-dicarboxyphenyl)-2,2＇,4,4＇,6,6＇-hexamethylbiphenyl)].　BUT-155　shows　high　porosity　with　a　Brunauer-Emmett-Teller　surface　area　of　2070　m(2)/g.　Quite　interestingly,　this　CP-MOF　retains　its　structural　integrity　after　being　treated　in　water　for　10　days　at　room　temperature　or　in　boiling　water　for　24　h.　To　the　best　of　our　knowledge,　BUT-15.5　represents　the　first　CP-MOF　that　is　demonstrated　to　retain　its　structural　integrity　in　boiling　water.　The　high　hydrolytic　stability　of　BUT-155　allowed　us　to　carry　out　adsorption　studies　of　water　vapor　and　aqueous　organic　pollutants　on　it.　Water-vapor　adsorption　reveals　a　sigmoidal　isotherm　and　a　high　uptake　(46.7　wt　%),　which　is　highly　reversible　and　regenerable.　In　addition,　because　of　the　availability　of　soft-acid-type　open　Cu(II)　sites,　BUT-155　shows　a　high　performance　for　selective　adsorption　of　soft-base-type　aniline　over　water　or　phenol,　and　a　naked-eye　detectable　color　change　for　the　MOF　sample　accompanies　this.　The　adsorption　selectivity　and　high　adsorption　capacity　of　aniline　in　BUT-155　are　also　well-interpreted　by　single-crystal　structures　of　the　water-　and　aniline-included　phases　of　BUT-15.5.