Synthesis of amphiphilic dextran-poly(lactide) copolymer and their nanoparticles as doxorubicin delivery systems - 文章详情页

作者：

Sun, J.-H. (Sun, J.-H..) (学者：孙继红) | Wen, L.-L. (Wen, L.-L..) | Wu, Y. (Wu, Y..) | Wang, H. (Wang, H..) | Li, Y.-W. (Li, Y.-W..)

收录：

Scopus PKU CSCD

摘要：

Novel　biodegradable　amphiphilic　copolymer　nanoparticles　based　on　dextran　and　poly(lactide)　have　been　prepared.　To　estimate　the　feasibility　as　drug　carriers,　an　anti-tumor　model　drug　doxorubicin　(DOX)　was　successfully　incorporated　into　polymeric　nanoparticles　by　double　emulsion　(DE)　and　nanoprecipitation　(NP)　methods.　The　DOX-loaded　nanoparticles　were　confirmed　by　dynamic　light　scattering　(DLS),　transmission　electron　microscopy　(TEM)　and　ultraviolet　(UV)　absorption　spectrometry.　The　DOX-loaded　nanoparticle　size,　size　distribution　and　encapsulation　efficiency　(EE)　were　influenced　by　the　feed　weight　ratio　of　the　copolymer　to　DOX.　In　addition,　in　vitro　release　experiments　exhibited　the　release　behavior　was　affected　by　pH　of　release　media.　The　DOX-loaded　nanoparticles　release　slower　in　pH　7.4　than　in　pH　5.0　buffer.　The　dextran-co-PLA　polymeric　nanoparticles　can　be　useful　as　drug　carriers　for　anti-tumor　drug　delivery.

关键词：

Dextran; Grafted copolymer; In vitro release; L-lactide; Nanoparticles

作者机构：

[ 1 ] [Sun, J.-H.]College of Environmental and Energy Engineering, Beijing University of Technology, Beijing 100124, China
[ 2 ] [Wen, L.-L.]College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan 030024, China
[ 3 ] [Wu, Y.]National Center for Nanoscience and Technology, Chinese Academy of Science, Beijing 100190, China
[ 4 ] [Wang, H.]College of Environmental and Energy Engineering, Beijing University of Technology, Beijing 100124, China
[ 5 ] [Li, Y.-W.]College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan 030024, China

通讯作者信息：

孙继红
[Sun, J.-H.]College of Environmental and Energy Engineering, Beijing University of Technology, Beijing 100124, China

电子邮件地址：

jhsun@bjut.edu.cn

查看成果更多字段

成果类型
所属机构

所有年份指定年份从至