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摘要:
Long non-coding RNAs (IncRNAs) are defined as a class of RNA transcripts longer than 200 nucleotides encoded by mammalian genomes that lack protein-coding potential. LncRNA ASBEL has been identified as an anti-sense transcript of BTG3 (B cell translocation gene 3) gene, which encodes an anti-proliferation protein. Remarkable down-regulation of BTG3 has been reported in triple-negative breast cancer (TNBC). In the present study, a number of single-stranded modified anti-sense DNA oligonucleotides (antago) were designed, synthesized and screened for specific IncRNA ASBEL knockdown. We showed here that anti-ASBEL antago played a significant tumor suppressive role in TNBC by effective down-regulating IncRNA ASBEL, which in turn led to increased BTG3 expression. The obtained data suggest IncRNA ASBEL as a novel therapeutic target in TNBC. (C) 2017 Elsevier Inc. All rights reserved.
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来源 :
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN: 0006-291X
年份: 2017
期: 4
卷: 489
页码: 386-392
3 . 1 0 0
JCR@2022
ESI学科: BIOLOGY & BIOCHEMISTRY;
ESI高被引阀值:215
中科院分区:3
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