Emerging　evidence　suggests　that　epitranscriptional　modifications　influence　multiple　cellular　processes.　N6-methyladenosine　(m(6)A),　as　the　most　abundant　reversible　methylation　of　mRNA,　has　also　been　reported　to　play　critical　roles　in　modulating　embryonic　stem　cell　differentiation　and　somatic　cell　reprogramming　by　regulating　gene　expression.　This　review　examined　the　characteristics　of　m(6)A,　including　the　distribution　profile　and　currently　discovered　＂writer,＂　＂eraser,＂　and　＂reader＂　proteins.　Moreover,　the　hypothesis　is　proposed　that　m(6)A　could　influence　cell　fate　determination,　and　the　underlying　mechanisms　are　due　to　the　related　mRNA　degradation,　causing　weakening　of　previous　cell　characteristics　and　eventually　leading　them　to　develop　into　the　reverse　direction　(pluripotency　or　differentiation　state).　Accordingly,　m(6)A　modifications　presented　its　potential　role　in　cell　fate　determination,　which　provides　new　insights　into　understanding　the　mechanisms　of　various　diseases.