Dissolution　of　metal　oxides　is　fundamentally　important　for　understanding　mineral　evolution　and　micromachining　oxide　functional　materials.　In　general,　dissolution　of　metal　oxides　is　a　slow　and　inefficient　chemical　reaction.　Here,　by　introducing　oxygen　deficiencies　to　modify　the　surface　chemistry　of　oxides,　we　can　boost　the　dissolution　kinetics　of　metal　oxides　in　water,　as　in　situ　demonstrated　in　a　liquid　environmental　transmission　electron　microscope　(LETEM).　The　dissolution　rate　constant　significantly　increases　by　16-19　orders　of　magnitude,　equivalent　to　a　reduction　of　0.97-1.11　eV　in　activation　energy,　as　compared　with　the　normal　dissolution　in　acid.　It　is　evidenced　from　the　high-resolution　TEM　imaging,　electron　energy　loss　spectra,　and　first-principle　calculations　where　the　dissolution　route　of　metal　oxides　is　dynamically　changed　by　local　interoperability　between　altered　water　chemistry　and　surface　oxygen　deficiencies　via　electron　radiolysis.　This　discovery　inspires　the　development　of　a　highly　efficient　electron　lithography　method　for　metal　oxide　films　in　ecofriendly　water,　which　offers　an　advanced　technique　for　nanodevice　fabrication.