A　series　of　benzofuran　derivatives　were　designed　and　synthesized,　and　their　inhibitory　activites　were　measured　against　the　SIRT1-3.　The　enzymatic　assay　showed　that　all　the　compounds　showed　certain　anti-SIRT2　activity　and　selective　over　SIRT1　and　SIRT3　with　IC50　(half　maximal　inhibitory　concentration)　values　at　the　micromolar　level.　The　preliminary　structure-activity　relationships　were　analyzed　and　the　binding　features　of　compound　7e　(IC50　3.81　mu　M)　was　predicted　using　the　CDOCKER　program.　The　results　of　this　research　could　provide　informative　guidance　for　further　optimizing　benzofuran　derivatives　as　potent　SIRT2　inhibitors.