The　Pd　catalyst　supported　on　cryptomelane-type　manganese　oxide　octahedral　molecular　sieve　(OMS-2)　were　prepared.　The　effect　of　Pd　loading　on　the　catalytic　oxidation　of　carbon　monoxide,　toluene,　and　ethyl　acetate　over　xPd/OMS-2　has　been　investigated.　The　results　show　that　the　Pd　loading　plays　an　important　role　on　the　physicochemical　properties　of　the　xPd/OMS-2　catalysts　which　outperform　the　Pd-free　counterpart　with　the　0.5Pd/OMS-2　catalyst　being　the　best.　The　temperature　for　50%　conversion　was　25,　240　and　160　degrees　C,　and　the　temperature　for　90%　conversion　was　55,　285　and　200　degrees　C　for　oxidation　of　CO,　toluene,　and　ethyl　acetate,　respectively.　The　low-temperature　reducibility　and　high　oxygen　mobility　of　xPd/OMS-2　are　the　factors　contributable　to　the　excellent　catalytic　performance　of　0.5Pd/OMS-2.