Electrochemiluminescence　assay　integrates　the　advantages　of　electrochemical　potential　controllability　and　high　sensitivity　of　luminescence　analysis.　The　electrochemiluminescence　sensor　was　fabricated　to　detect　the　DNA　damage.　CdS　quantum　dots　were　deposited　on　the　surface　of　glass　carbon　electrode　in　0.1　M　CdC12　and　0.02　M　Na2S2O3　(0.1　M　HC1,　pH　2-3,　50　°C)　by　cyclic　voltammetry,　and　then　the　amino-modified　single　strand　DNA　was　immobilized　on　CdS　modified　electrode　by　the-CONH-bond　using　cysteine　as　linker　agent.　The　electrochemiluminescence　was　used　to　study　the　interaction　between　perfluorooctane　sulfonates　and　DNA,　and　H2O2　was　used　as　the　common　reactant.　The　results　demonstrated　that　the　intensity　of　electrochemiluminescence　signal　increased　with　the　increasing　of　perfluorooctane　sulfonates　concentration.　Meanwhile,　the　electrochemical　impedance　spectroscopy　indicated　that　the　DNA　charge　transfer　attenuated　with　the　incubation　of　perfluorooctane　sulfonates.　These　results　reveal　that　perfluorooctane　sulfonates　can　induce　the　distortion　and　change　of　DNA　chain.　©　2013,　Changchun　Institute　of　Applied　Chemistry.