The　hollow　magnetic　mesoporous　SiO2/Fe3O4　microspheres　with　different　pore　sizes　were　prepared　by　adjusting　the　addition　of　swelling　agent　(1,　3,　5-trimethylbenzene).　The　hollow　magnetic　mesoporous　SiO2/Fe3O4　microspheres　were　modificated　with　different　degree　of　aminopropyl　groups　via　co-condensation　method.　The　specific　surface　area,　pore　size,　pore　volume　and　ibuprofen　loading　of　obtained　composite　microspheres　were　investigated　in　detail.　The　results　showed　that　ibuprofen　loading　was　increased　with　the　mesoporous　size　increasing,　and　addition　of　swelling　agent　can　improve　the　mesoporous　size.　When　the　pore　size　was　up　to　3.79　nm,　ibuprofen　reached　the　highest　loading　amount　(816　mg/g).　After　modification　of　the　aminopropyl　group,　which　was　located　in　the　mesoporous　channel,　the　ibuprofen　loading　was　slightly　reduced　but　the　release　rate　of　IBU　was　significantly　decreased.　Optimal　release　properties　were　achieved　when　the　modification　amount　of　the　aminopropyl　group　was　10%,　the　ibuprofen　continued　to　be　released　even　after　32　h　and　the　total　release　quantity　is　70%,　while　the　IBU　release　amount　was　93%　in　the　non-functionalized　composite　microspheres　in　12　h.　Meanwhile,　the　Korsmeyer-Peppas　equation　Q　=　kt　(n)　was　employed　to　analyze　the　drug　release　profile.　The　hollow　magnetic　mesoporous　SiO2/Fe3O4　microspheres　had　a　high　magnetization　saturation　value　of　39.4　emu/g,　which　demonstrated　a　good　responsivity　to　magnetic　fields.