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Author:

Li, Qun-Yan (Li, Qun-Yan.) | Ma, Kai-Rui (Ma, Kai-Rui.) | Zhou, Yun-Lu (Zhou, Yun-Lu.) | Nie, Zuo-Ren (Nie, Zuo-Ren.) (Scholars:聂祚仁) | Wei, Qi (Wei, Qi.)

Indexed by:

EI Scopus SCIE

Abstract:

The hollow magnetic mesoporous SiO2/Fe3O4 microspheres with different pore sizes were prepared by adjusting the addition of swelling agent (1, 3, 5-trimethylbenzene). The hollow magnetic mesoporous SiO2/Fe3O4 microspheres were modificated with different degree of aminopropyl groups via co-condensation method. The specific surface area, pore size, pore volume and ibuprofen loading of obtained composite microspheres were investigated in detail. The results showed that ibuprofen loading was increased with the mesoporous size increasing, and addition of swelling agent can improve the mesoporous size. When the pore size was up to 3.79 nm, ibuprofen reached the highest loading amount (816 mg/g). After modification of the aminopropyl group, which was located in the mesoporous channel, the ibuprofen loading was slightly reduced but the release rate of IBU was significantly decreased. Optimal release properties were achieved when the modification amount of the aminopropyl group was 10%, the ibuprofen continued to be released even after 32 h and the total release quantity is 70%, while the IBU release amount was 93% in the non-functionalized composite microspheres in 12 h. Meanwhile, the Korsmeyer-Peppas equation Q = kt (n) was employed to analyze the drug release profile. The hollow magnetic mesoporous SiO2/Fe3O4 microspheres had a high magnetization saturation value of 39.4 emu/g, which demonstrated a good responsivity to magnetic fields.

Keyword:

Functionalized Drug loading Ibuprofen Mesoporous SiO2 Fe3O4

Author Community:

  • [ 1 ] [Li, Qun-Yan]Beijing Univ Technol, Coll Mat Sci & Engn, 100 Pingleyuan, Beijing 100124, Peoples R China
  • [ 2 ] [Ma, Kai-Rui]Beijing Univ Technol, Coll Mat Sci & Engn, 100 Pingleyuan, Beijing 100124, Peoples R China
  • [ 3 ] [Zhou, Yun-Lu]Beijing Univ Technol, Coll Mat Sci & Engn, 100 Pingleyuan, Beijing 100124, Peoples R China
  • [ 4 ] [Nie, Zuo-Ren]Beijing Univ Technol, Coll Mat Sci & Engn, 100 Pingleyuan, Beijing 100124, Peoples R China
  • [ 5 ] [Wei, Qi]Beijing Univ Technol, Coll Mat Sci & Engn, 100 Pingleyuan, Beijing 100124, Peoples R China

Reprint Author's Address:

  • [Li, Qun-Yan]Beijing Univ Technol, Coll Mat Sci & Engn, 100 Pingleyuan, Beijing 100124, Peoples R China

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Source :

JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY

ISSN: 0928-0707

Year: 2017

Issue: 3

Volume: 82

Page: 692-701

2 . 5 0 0

JCR@2022

ESI Discipline: MATERIALS SCIENCE;

ESI HC Threshold:287

CAS Journal Grade:3

Cited Count:

WoS CC Cited Count: 4

SCOPUS Cited Count: 4

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 0

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