To　consider　the　actual　fire　characteristics　in　the　fire　response　analysis　of　building　structures　and　simplify　the　complex　relationship　between　the　fire　analysis　model　and　the　structural　finite　element　analysis　model,　a　spatio-temporal　model　of　fire　temperature　and　heat　flux　boundary　for　heat　conduction　analysis　was　developed.　The　model　adopted　the　2-way　orthogonal　polynomial　approach　to　fit　the　discrete　data　from　fire　simulation　and　obtained　the　continuous　spatial　polynomial　equations,　which　was　proved　to　be　accurate　for　capturing　the　distribution　of　temperature　and　heat　flux　required　in　heat　conduction　analysis　and　thermo-mechanical　coupling　analysis.　Finally,　the　model　was　applied　through　user　subroutines　UTEMP　and　DFLUX　in　ABAQUS　to　the　fire　resistance　analysis　of　a　new　archive　building　in　Beijing.　The　results　show　that　this　method　can　be　used　to　combine　fire　simulation　and　structural　analysis　for　safety　evaluation　of　structures　under　fire.　©　2017　Elsevier　B.V.　All　rights　reserved.