Integration　of　land　use　and　transportation　planning　with　current　and　future　spatial　distributions　of　population　and　employment　is　a　challenge　but　critical　to　sustainable　planning　outcomes.　The　challenge　is　specific　to　how　sustainability　factors　(e.g.,　carbon　dioxide　emission),　and　land　use　and　socioeconomic　changes　are　considered　in　a　streamlined　manner.　To　address　the　challenge,　this　paper　presents　an　integrated　modeling　and　computing　framework　for　systemic　analysis　of　regional-　and　project-level　transportation　environmental　impacts　for　land　use　mix　patterns　and　associated　transportation　activities.　A　synthetic　computing　platform　has　been　developed　to　facilitate　the　scenario-based　quantitative　analysis　of　cause-and-effect　mechanisms　between　land　use　changes　and/or　traffic　management　and　control　strategies,　their　impacts　on　traffic　mobility　and　the　environment.　Within　the　integrated　platform,　multiple　models　for　land　use　pattern,　travel　demand　forecasting,　traffic　simulation,　vehicle　and　carbon　emission,　and　other　operation　and　sustainability　measures　are　integrated　using　mathematical　models　in　a　Geographical　Information　System　environment.　Furthermore,　a　case　study　of　the　Greater　Cincinnati　area　at　regional　level　is　performed　to　test　the　integrated　functionality　as　a　capable　tool　for　urban　planning,　transportation　and　environmental　analysis.　The　case　study　results　indicate　that　such　an　integration　investigation　can　help　assess　strategies　in　land　use　planning　and　transportation　systems　management　for　improved　sustainability.　©　2017,　The　Author(s).