The　fabrication　of　nanoporous　anatase　TiO2　on　a　microstructured　Ti　base　is　achieved　through　an　innovative　hybrid　fabrication　method　involving　femtosecond　laser　ablation　coupled　with　H2O2　oxidation　and　annealing.　The　anatase　TiO2　micro-nanostructures　have　superior　photocatalytic　degradation　of　methyl　orange　due　to　enhanced　light　harvesting　capacity　and　surface　area.　The　photodegradation　efficiency　increases　by　a　maximum　of　80%　compared　to　the　nanoporous　anatase　TiO2　fabricated　through　H2O2　oxidation　and　annealing　only　(without　femtosecond　laser　ablation).　Meanwhile,　The　anatase　TiO2　micro-nanostructures　show　good　cyclic　performance,　indicating　a　great　potential　for　practical　application.　The　proposed　hybrid　method　can　easily　tune　the　morphology　and　size　of　microstructure　by　simply　adjusting　the　femtosecond　laser　parameters,　showing　advantage　in　fabricating　of　micro-nanostructures　with　a　rich　variety　of　morphologies.