To　study　the　deformation　and　mechanical　characteristics　during　expansion　process　of　vascular　stent　in　realistic　stenosis　model,　so　as　to　provide　scientific　references　for　interventional　treatment　and　stent　design.　The　carotid　vessel　model　and　plaque　model　of　patient　were　built　by　using　3D　reconstruction　method,　and　the　stent　model　with　I-shaped　link　was　established　by　using　Pro/E;　ABAQUS/Standard　was　used　to　simulate　the　radial　expansion　(the　first　stage)　and　radial　contraction　(the　second　stage)　of　the　stent　in　real　stenosis　model,　and　a　realistic　model　of　blood　vessel　with　plaque　was　also　established　to　make　contrast　test.　In　the　first　stage,　radial　expansion　of　the　stent　was　formed.　The　maximum　contact　area　was　generated　between　the　outer　surface　of　the　stent　and　the　inner　surface　of　the　plaque/arterial　wall,　and　the　maximum　stresses　on　the　stent,　plague　and　arterial　wall　were　515.000,　2.482,　1.053　MPa,　respectively.　In　the　second　stage,　the　radial　contraction　of　the　stent　resulted　in　“　dog-bone”　effect.　Many　gaps　between　the　stent　and　vessel　wall　was　formed,　and　the　maximum　stresses　on　the　stent,　plague　and　arterial　wall　were　464.500,　0.954,　0.316　MPa,　respectively.　In　contrast　test,　the　maximum　stresses　on　stenotic　vessel　and　stent　were　0.9,　414.1　MPa　in　the　second　stage.　Compared　with　the　model　in　contrast　test,　the　stenosis　model　differentiating　the　component　of　vascular　tissues　is　more　consistent　with　the　real　situation　of　stenotic　vessels,　by　more　truly　showing　deformation　and　mechanical　characteristics　of　the　stent　and　blood　vessel.　The　stent　causes　the　maximum　damage　to　plaque　and　inner　wall　of　blood　vessel　in　the　first　stage,　while　“　dog-bone”　effect　of　the　stent　is　an　important　influencing　factor　that　results　in　the　gaps　between　the　stent,　plague　and　blood　vessel.　These　research　findings　may　provide　significant　guidance　for　selecting　stent　in　interventional　treatment　and　improving　stent　design.　©　2015,　Editorial　Office　of　Journal　of　Medical　Biomechanics.　All　right　reserved.