To　objectively　measure　the　advantages　and　disadvantages　of　traffic　guide　sign　layout,　the　effectiveness　on　ergonomics　of　traffic　guide　sign　layout　was　quantitatively　studied　using　multidimensional　data.　Fully　considering　information　demand　and　information　process,　information　demand,　comprehension　level,　and　information　content　were　introduced,　and　the　ergonomics　evaluation　model　of　traffic　guide　sign　layout　was　established.　It　is　more　reasonable　for　signs　to　guide　the　routes　that　are　close　to　the　intersection　and　the　important　destinations　that　are　nearby;　and　the　arrangement　of　letters　on　the　signs　that　is　consistent　with　the　direction　of　the　roads,　and　the　letters　that　are　converted　into　the　graphic　symbols　can　improve　the　comprehension　level　of　signs.　Results　show　that　ergonomics　evaluation　of　traffic　guide　sign　layout　can　more　accurately　image　whether　the　layout　of　signs　meets　the　driver＇s　information　demand;　complies　with　the　law　of　drive＇s　perception;　and　facilitates　driver＇s　understanding　of　roadway　configuration,　and　can　be　an　effective　measurement　for　studying　the　coordination　among　drivers,　traffic　guide　signs,　and　roads.　©,　2015,　Beijing　University　of　Technology.　All　right　reserved.