As　the　key　connecting　part　of　the　electrical　discharge　machine　(EDM),　the　slide　of　cross-saddle　type　directly　impacts　the　machine　tool＇s　machining　accuracy.　In　this　paper,　the　friction　heats　of　the　bearing　and　ball　screw　pair　are　the　main　heat　source,　considering　the　thermal　contact　resistance　(TCR),　making　the　coupled　thermos-mechanical　deformation　analysis　for　the　slide　applied　the　finite　element　analysis　(FEA)　software.　According　to　the　analysis　result,　the　temperature　field　and　thermal　deformation　considering　the　TCR　are　closer　to　the　actual　working　condition;　in　addition,　proposed　two　kinds　of　optimization　design　structures.　Using　the　same　conditions　to　analyze　these　structures,　finding　that　a　drop　in　temperature　and　the　thermal　deformation,　especially　the　cellular　form　of　stiffened　plate　structure.　The　analysis　results　not　only　provide　a　basis　that　the　further　optimization　of　the　slide　structure,　but　also　highlight　the　advantages　of　the　honeycomb　structure.　©　JVE　International　Ltd.