Here　a　series　of　novel　5　alpha,8　alpha-epidioxyandrostan-3　beta-ol-17-hydrazone　derivatives　possessing　various　aromatic　heterocycle　structures　in　17-side　chain　of　their　steroidal　nucleus　were　synthesized　and　characterized.　The　antiproliferative　activity　of　synthesized　compounds　against　some　cancer　cells　was　investigated.　The　results　have　demonstrated　that　compound　8b　with　quinoline　and　8c　with　indole　structure　in　side　chain　display　excellent　anti-proliferative　activity　in　vitro　against　tested　cancer　cell　lines.