Background:　Anemia　is　a　prevalent　complication　in　heart　failure　patients,　which　relates　to　poor　prognosis.　Left　ventricular　assist　device　(LVADs),　as　an　important　therapy　for　heart　failure,　is　confirmed　to　impair　the　structure　and　function　of　erythrocytes,　which　may　aggravate　the　degree　of　anemia.　However,　the　precise　effect　of　LVADs　on　anemia　in　clinical　practice　is　unclear.　Hence,　we　conducted　a　meta-analysis　to　clarify　the　effect　of　left　ventricular　assist　devices　(LVADs)　on　anemia　in　patients　with　heart　failure.　Material/Methods:　Relevant　studies　through　August　2014　were　searched　and　identified　in　Medline,　Cochrane　Library,　Web　of　Science,　and　Science　Direct　online　databases.　Studies　that　reported　standard　mean　difference　estimates　with　95%　confidence　intervals　(CIs)　for　the　associations　of　interest　were　included.　Data　were　extracted　and　summary　estimates　of　associations　were　obtained　using　the　inverse-variance　fixed-effects　model.　Results:　Of　the　7　studies　included,　2　studies　evaluated　anemia　in　patients　with　advanced　heart　failure　receiving　longterm　mechanical　circulatory　support.　Five　studies　estimated　the　hemoglobin　in　patients　with　left　ventricular　assist　device　(LVADs)　support.　The　standard　mean　differences　of　LVADs　were　0.05(95%　CI:　–0.03　to　0.12;　p=0.23)　for　hemoglobin,　–0.65　(95%　CI:　–0.79　to　–0.51;　p＜0.00001)　for　BUN,　and　–0.39(95%　CI:　–0.53　to　–0.26;　p＜0.00001)　for　creatinine.　The　standard　mean　differences　of　anemia　with　LVADs　support　were　–0.11(95%　CI:　–0.46　to　0.24;　p=0.54)　for　hemoglobin,　–0.24　(95%　CI:　–0.59　to　0.12;　p=0.19)　for　blood　urea　nitrogen　(BUN),　and　–0.06(95%　CI:　–0.41　to　0.29;　p=0.73)　for　creatinine.　Conclusions:　There　is　no　statistical　difference　in　the　effect　of　LVADs　on　hemoglobin　between　pre-　and　pro-implantation　LVADs.　In　contrast,　the　implantation　of　LVADs　is　confirmed　to　improve　the　state　of　BUN　and　creatinine　for　heart　failure　patients;　LVADs　have　a　similar　effect　on　the　change　of　hemoglobin　for　anemia　and　no-anemia　patients.　The　effects　of　LVADs　on　BUN　and　creatinine　for　patients　with　and　without　anemia　were　not　significantly　different.　The　differences　in　the　effects　of　LVADs　on　hemoglobin,　BUN,　and　creatinine　of　patients　could　provide　useful　information　for　establishing　clinical　strategies.　©　Med　Sci　Tech.