The　Ti-modified　sepiolite　(Ti-Sep)-supported　Mn-Cu　mixed　oxide　(yMn5Cu/Ti-Sep)　catalysts　were　synthesized　using　the　co-precipitation　method.　The　materials　were　characterized　by　the　X-ray　diffraction　scanning　electron　microscope,　N-2　adsorption-desorption,　H-2-TPR,　O-2-TPD,　and　XPS　techniques,　and　their　catalytic　activities　for　CO　oxidation　were　evaluated.　It　was　found　that　the　catalytic　activities　of　yMn5Cu/Ti-Sep　were　higher　than　those　of　5Cu/Ti-Sep　and　30Mn/Ti-Sep,　and　the　Mn/Cu　molar　ratio　had　a　distinct　influence　on　catalytic　activity　of　the　sample.　Among　the　yMn5Cu/Ti-Sep　samples,　the　30Mn5Cu/Ti-Sep　catalyst　showed　the　best　activity　(which　also　outperformed　the　30Mn5Cu/Sep　catalyst),　giving　the　highest　reaction　rate　of　0.875　x　10(-3)　mmol.g(-1).s(-1)　and　the　lowest　T-50%　and　T-100%　of　56　degrees　C　and　86　degrees　C,　respectively.　Moreover,　the　30Mn5Cu/Ti-Sep　possessed　the　best　low-temperature　reducibility,　the　lowest　O-2　desorption　temperature,　and　the　highest　surface　Mn3+/Mn4+　atomic　ratio.　It　is　concluded　that　factors,　such　as　the　strong　interaction　between　the　copper　or　manganese　oxides　and　the　Ti-Sep　support,　good　low-temperature　reducibility,　and　good　mobility　of　chemisorbed　oxygen　species,　were　responsible　for　the　excellent　catalytic　activity　of　30Mn5Cu/Ti-Sep.　(C)　Higher　Education　Press　and　Springer-Verlag　Berlin　Heidelberg　2017