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作者:

Li, Lanlan (Li, Lanlan.) | Liu, Youjun (Liu, Youjun.) (学者:刘有军) | Zhao, Xi (Zhao, Xi.) | Mao, Boyan (Mao, Boyan.) | Zhang, Huixia (Zhang, Huixia.)

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摘要:

Background and Aims: Competitive flow exists in the native coronary artery when using artery graft in the coronary artery bypass graft (CABG), and it is a major factor affecting the long-term patency of the arterial grafts. The purpose of this study is to investigate the effects of the competitive flow on hemodynamic characteristics of left internal mammary artery (LIMA). Materials and methods: Seven three-dimensional (3D) LIMA-left anterior decending (LAD) grafting models with different diameter stenoses at the trunk of LAD were reconstructed, including 25%, 40%, 50%, 60%, 75%, 90% and 100%. The boundary conditions of these models were provided by the same lumped parameter model (LPM; 0D sub-model) of cardiovascular circulatory system, which is based on 0D/ 3D coupling method. Results: The simulation results show that competitive flow decreases when the stenosis rate increases and backflow exists in LIMA during systole when the degree of stenosis is below 50%; the wall shear stress (WSS) of the graft increases from 0.85 Pa to 1.79 Pa with the increase of the native coronary stenosis degree, while the oscillatory shear index (OSI) decreases from 0.1557 to 0.00213. Conclusions: Competitive flow may produce adverse hemodynamic effects on artery graft, especially when the stenosis degree is below 50%, competitive flow will significantly lead the long-term patency of the artery graft worse because of the backflow, low WSS and high OSI, and the effect of OSI is more obvious than WSS.

关键词:

long-term patency hemodynamics Competitive flow CABG the lumped parameter model

作者机构:

  • [ 1 ] [Li, Lanlan]Beijing Univ Technol, Coll Life Sci & Bioengn, 100 Pingleyuan, Beijing 100124, Peoples R China
  • [ 2 ] [Liu, Youjun]Beijing Univ Technol, Coll Life Sci & Bioengn, 100 Pingleyuan, Beijing 100124, Peoples R China
  • [ 3 ] [Zhao, Xi]Beijing Univ Technol, Coll Life Sci & Bioengn, 100 Pingleyuan, Beijing 100124, Peoples R China
  • [ 4 ] [Mao, Boyan]Beijing Univ Technol, Coll Life Sci & Bioengn, 100 Pingleyuan, Beijing 100124, Peoples R China
  • [ 5 ] [Zhang, Huixia]Beijing Univ Technol, Coll Life Sci & Bioengn, 100 Pingleyuan, Beijing 100124, Peoples R China

通讯作者信息:

  • 刘有军

    [Liu, Youjun]Beijing Univ Technol, Coll Life Sci & Bioengn, 100 Pingleyuan, Beijing 100124, Peoples R China

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来源 :

JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY

ISSN: 0219-5194

年份: 2017

期: 2

卷: 17

0 . 8 0 0

JCR@2022

ESI学科: MOLECULAR BIOLOGY & GENETICS;

ESI高被引阀值:309

中科院分区:4

被引次数:

WoS核心集被引频次: 4

SCOPUS被引频次: 6

ESI高被引论文在榜: 0 展开所有

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