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作者:

Zhang, Qi (Zhang, Qi.) | Gao, Bin (Gao, Bin.) | Chang, Yu (Chang, Yu.) (学者:常宇)

收录:

Scopus SCIE

摘要:

Background: Partial support, as a novel support mode, has been widely applied in clinical practice and widely studied. However, the precise mechanism of partial support of LVAD in the intra-ventricular flow pattern is unclear. Material/Methods: In this study, a patient-specific left ventricular geometric model was reconstructed based on CT data. The intra-ventricular flow pattern under 3 simulated conditions - "heart failure", "partial support", and "full support" - were simulated by using fluid-structure interaction (FSI). The blood flow pattern, wall shear stress (WSS), time-average wall shear stress (TAWSS), oscillatory shear index (OSI), and relative residence time (RRT) were calculated to evaluate the hemodynamic effects. Results: The results demonstrate that the intra-ventricular flow pattern is significantly changed by the support level of BJUT-II VAD. The intra-ventricular vortex was enhanced under partial support and was eliminated under full support, and the high OSI and RRT regions changed from the septum wall to the cardiac apex. Conclusions: In brief, the support level of the BJUT-II VAD has significant effects on the intra-ventricular flow pattern. The partial support mode of BJUT-II VAD can enhance the intra-ventricular vortex, while the distribution of high OSI and RRT moved from the septum wall to the cardiac apex. Hence, the partial support mode of BJUT-II VAD can provide more benefit for intra-ventricular flow pattern.

关键词:

Ventricular Remodeling Hemodynamics Heart-Assist Devices

作者机构:

  • [ 1 ] [Zhang, Qi]Beijing Univ Technol, Sch Life Sci & BioEngn, Beijing, Peoples R China
  • [ 2 ] [Gao, Bin]Beijing Univ Technol, Sch Life Sci & BioEngn, Beijing, Peoples R China
  • [ 3 ] [Chang, Yu]Beijing Univ Technol, Sch Life Sci & BioEngn, Beijing, Peoples R China

通讯作者信息:

  • 常宇

    [Chang, Yu]Beijing Univ Technol, Sch Life Sci & BioEngn, Beijing, Peoples R China

电子邮件地址:

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来源 :

MEDICAL SCIENCE MONITOR

ISSN: 1643-3750

年份: 2017

卷: 23

页码: 1043-1054

3 . 1 0 0

JCR@2022

ESI学科: CLINICAL MEDICINE;

ESI高被引阀值:190

中科院分区:4

被引次数:

WoS核心集被引频次: 5

SCOPUS被引频次: 5

ESI高被引论文在榜: 0 展开所有

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