On　the　basis　of　briefly　introducing　cellular　automata　(CA)　basic　concept,　underlying　property　and　simulation　modeling　steps　using　CA,　the　applications　of　CA　in　modeling　and　simulation　of　penicillin　fermentation　process　biomass　growth　was　studied.　First,　a　penicillin　batch　fermentation　process　biomass　growth　simulation　model　based　on　CA　was　established,　and　then　the　program　of　this　model　was　composed　using　Matlab.　The　simulation　experiment　results　of　the　program　show　that　the　cellular　automata　simulation　model　well　describes　the　evolution　behavior　of　penicillin　fermentation　process　biomass　growth,　the　ability　of　cellular　automata　for　simulating　complex　physical　phenomenon　or　process　is　very　powerful,　and　cellular　automata　are　ideal　artificial　life　calculation　models　for　modeling　and　simulation　of　penicillin　fermentation　processes.