Background　and　aims:　Sequential　grafting　is　one　of　the　common　coronary　artery　bypass　grafting　(CABG)　surgery.　But　the　influence　of　the　sequential　grafting　position　on　hemodynamics　and　the　graft　patency　is　still　unclear.　Materials　and　methods:　The　zero-dimensional/three-dimensional　(0D/3D)　coupling　method　was　used　to　finalize　the　multi-scale　simulation　of　two　different　sequential　grafting　models.　First,　a　patient-specific　3D　model　was　reconstructed　based　on　coronary　computed　tomography　angiography　(CCTA)　images.　Two　different　sequential　grafts　were　implemented　on　this　patient-specific　3D　model　by　using　virtual　surgery.　Thus,　two　different　postoperative　3D　models　were　built.　Then,　a　lumped　parameter　model　(LPM;　0D)　was　built　based　on　the　patient　physiological　data　to　simulate　the　cardiovascular　system.　Finally,　the　0D/3D　coupling　method　was　used　to　perform　the　numerical　simulation　by　coupling　a　0D　LPM　of　the　cardiovascular　system　and　the　patient-specific　3D　models.　Moreover,　the　long-term　patency　of　these　two　different　sequential　grafts　was　discussed　in　this　paper.　Results:　The　coronary　flow　rate　and　the　graft　flow　were　calculated　and　illustrated.　The　instantaneous　wave-free　ratio　(iFR)　were　calculated.　Postoperative　iFR　values　increase　to　over　0.90　for　both　sequential　grafts.　Some　hemodynamics　parameters　were　also　illustrated,　such　as　wall　shear　stress　(WSS),　oscillatory　shear　index　(OSI).　The　area　of　low　WSS　in　Model　1　was　much　less　than　that　in　Model　2.　Two　regions　of　high　OSI　exist　in　Model　2,　while　only　one　in　Model　1.　Conclusions:　No　significant　differences　exist　on　the　short-term　outcomes　of　two　models.　But　the　long-term　patency　of　Model　2　was　worse.　The　Model　1　may　enhance　long-term　patency　of　grafting　and　should　be　priority　when　the　sequential　grafting　need　to　be　carried　out.