The　objective　of　this　paper　is　to　study　the　size　effect　in　eccentrically　loaded　stocky　reinforced　concrete　(RC)　columns　from　both　experimental　and　numerical　perspectives.　An　experimental　campaign　was　carried　out　on　eccentrically　loaded　RC　columns　of　full-scale　to　facilitate　a　more　accurate　understanding　of　the　influence　of　eccentricity　on　the　failure　behavior　and　size　effect.　A　total　of　30　geometrically　similar　RC　columns　sized　from　200x200x900mm　to　800x800x3,600mm　was　tested　with　the　eccentricities　of　0.1h0,　0.25h0,　0.4h0,　0.6h0,　and　0.9h0　(h0　denotes　the　effective　cross-sectional　height).　A　brittle-ductile　transition　behavior　according　to　the　initial　eccentricity　was　found　from　the　test　observations,　and　a　comparison　of　the　present　test　results　and　the　SEL　proposed　by　Baant　was　made.　Meanwhile,　a　mesoscale　numerical　method　for　the　simulation　of　failure　behavior　of　RC　columns　was　proposed.　Good　agreement　between　the　present　simulation　results　and　the　test　observations　of　the　RC　columns　without　transversal　reinforcement　illustrates　the　reliability　and　accuracy　of　the　numerical　approach.　The　verified　mesoscale　approach　was　then　extended　to　study　the　failure　behavior　of　RC　columns　having　transversal　reinforcement,　and　the　confinement　effect　was　also　discussed.　(C)　2016　American　Society　of　Civil　Engineers.