Structure-Function Relationship of Proteins Based on the Elastic Network Model - 文章详情页

作者：

Ding, X. (Ding, X..) | Mi, C. (Mi, C..) | Chen, W. (Chen, W..) | Su, J. (Su, J..) | Wang, C. (Wang, C..)

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Scopus PKU CSCD

摘要：

Protein　structure-function　relationship　is　one　of　the　hot　problems　in　the　research　field　of　structural　biology　with　theoretical　and　practical　significances.　Elastic　network　model　(ENM)　is　an　effective　method　to　investigate　the　intrinsic　dynamical　properties　encoded　in　protein　structure　and　then　explore　the　biological　functions　of　proteins,　which　has　been　widely　used　in　the　studies　of　protein　structure-function　relationship.　In　this　paper,　the　basic　theory　of　ENM　as　well　as　its　applications　in　the　studies　of　protein　structure-function　relationship　are　introduced,　including　the　analysis　of　protein　functional　motions　and　the　identification　of　key　sites　in　proteins.　©　2017,　Editorial　Department　of　Journal　of　Beijing　University　of　Technology.　All　right　reserved.

关键词：

Elastic network model; Functional motion; Key sites; Normal mode analysis; Protein structure-function relationship

作者机构：

[ 1 ] [Ding, X.]Key Laboratory for Microstructural Material Physics of Hebei Province, College of Science, Yanshan University, Qinhuangdao, 066004, China
[ 2 ] [Mi, C.]Key Laboratory for Microstructural Material Physics of Hebei Province, College of Science, Yanshan University, Qinhuangdao, 066004, China
[ 3 ] [Chen, W.]College of Life Science and Bioengineering, Beijing University of Technology, Beijing, 100124, China
[ 4 ] [Su, J.]Key Laboratory for Microstructural Material Physics of Hebei Province, College of Science, Yanshan University, Qinhuangdao, 066004, China
[ 5 ] [Wang, C.]College of Life Science and Bioengineering, Beijing University of Technology, Beijing, 100124, China

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