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摘要 ：
In this study, confocal Raman spectroscopy was used to study the Sublethal damage erythrocytes of artificial heart pump under different shear stress to verify the ability of Raman spectroscopy to evaluate the degree of erythrocyte Sublethal damage. It provides a new idea for the evaluation of blood injury. The standard Raman spectra of hemoglobin and red blood cells were collected and compared in order to determine the peak intensity of erythrocytes. The sheer force of 0, 50, 100, 150, 200, 250 and 300 pa was applied to the tested blood samples for 1 s on the blood shear test platform. Using confocal Raman instrument, the Raman spectra of erythrocytes under shear stress were collected under 10 times long focal lens, 532 nm laser light source wavelength, integration time 10 s, twice, and 2. 5 mW. Through the normalization method to compare the changes of the Raman spectrum of red blood cells, evaluate the degree of red blood cell Sublethal damage, and use the curve fitting method to fit the characteristic peak and shear stress to verify the ability of Raman spectrum to evaluate the sub-injury of red blood cells. Comparing the standard Raman spectra of hemoglobin and red blood cells, it is found that the erythrocyte spectra can reflect the internal structure of hemoglobin. The results show that Raman spectroscopy can be used to distinguish the Sublethal damage erythrocytes under different shear stress, and it is inferred that the shear stress can pass through the cell membrane and affect the internal hemoglobin structure. With the increase of shear force, the left spectral line of 1 376 cm(-1) increased. Obviously, the peak intensity of 1 549 and 1 604 cm(-1) increased, and the vibration band of oxygen concentration marker band 10 at 1 639 cm(-1) decreased. Among them, the peak strength of 1 549 cm(-1) position is the high spin band of ferrous ion. Under the action of different shear forces, the difference of peak strength is the most obvious, which has an obvious positive linear relationship with the shear stress, and the fitting effect is good. Raman spectroscopy has the advantages of simple treatment, short time, simple operation and good reproducibility can accurately detect the subtle changes in the internal structure of cells, and evaluate the degree of sub-injury of red blood cells. it makes up for the deficiency of the traditional evaluation of hemolysis, provides a new technical means for the evaluation of blood injury caused by artificial heart pump, and broadens the application field of the Raman detection method.
关键词 ：
Shear stress Shear stress Blood injury Blood injury Red blood cell Red blood cell Raman spectroscopy Raman spectroscopy Artificial hear Artificial hear Hemoglobin Hemoglobin
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| GB/T 7714 | Wang Jin-shuang , Fu Ying-ying , Fu Min-rui et al. Study on Erythrocyte Sublethal Damage Under Different Shear Stress Based on Raman Spectroscopy [J]. | SPECTROSCOPY AND SPECTRAL ANALYSIS , 2021 , 41 (6) : 1811-1815 . |
| MLA | Wang Jin-shuang et al. "Study on Erythrocyte Sublethal Damage Under Different Shear Stress Based on Raman Spectroscopy" . | SPECTROSCOPY AND SPECTRAL ANALYSIS 41 . 6 (2021) : 1811-1815 . |
| APA | Wang Jin-shuang , Fu Ying-ying , Fu Min-rui , Gao Bin , Zheng Da-wei , Chang Yu . Study on Erythrocyte Sublethal Damage Under Different Shear Stress Based on Raman Spectroscopy . | SPECTROSCOPY AND SPECTRAL ANALYSIS , 2021 , 41 (6) , 1811-1815 . |
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摘要 ：
利用共聚焦拉曼光谱技术,对人工心脏泵不同剪切应力下受到亚损伤的红细胞进行实验研究,验证拉曼光谱对红细胞亚损伤程度的评估能力,为血液损伤评价提供了一种新的思路。实验采集血红蛋白和红细胞的拉曼光谱标准谱图并进行对比分析,以确定红细胞谱图特征峰的归属。用血液剪切力试验平台对测试血样施加暴露时间为1 s,大小分别为0, 50, 100, 150, 200, 250和300 pa的剪切力。利用共聚焦拉曼仪器,在10倍长焦物镜,532 nm激光光源波长,积分时间10 s,积分次数2次,2.5 mW功率下采集剪切应力作用后的红细胞拉曼谱图。通过归一化的方法对比红细胞的拉曼谱图变化,评估红细胞亚损伤的程度,运...
关键词 ：
人工心脏 人工心脏 血液损伤 血液损伤 剪切应力 剪切应力 血红蛋白 血红蛋白 红细胞 红细胞 拉曼光谱 拉曼光谱
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| GB/T 7714 | 王金爽 , 付莹莹 , 符珉瑞 et al. 基于拉曼光谱方法研究不同剪切力下的红细胞亚损伤 [J]. | 光谱学与光谱分析 , 2021 , 41 (06) : 1811-1815 . |
| MLA | 王金爽 et al. "基于拉曼光谱方法研究不同剪切力下的红细胞亚损伤" . | 光谱学与光谱分析 41 . 06 (2021) : 1811-1815 . |
| APA | 王金爽 , 付莹莹 , 符珉瑞 , 高斌 , 郑大威 , 常宇 . 基于拉曼光谱方法研究不同剪切力下的红细胞亚损伤 . | 光谱学与光谱分析 , 2021 , 41 (06) , 1811-1815 . |
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摘要 ：
The STM CP-24 I centrifugal pump is a newly developed centrifugal pump for extracorporeal membrane oxygenation equipment. This study aimed to combine hydraulic experiments, hemodynamic numerical simulations, and standard in vitro hemolysis experiments to investigate the comprehensive performance of this centrifugal pump.In vitro experiments were first done to obtain the pressure-flow data of the centrifugal pump in its working range to evaluate its hydraulic performance. Next, the commonly used clinical working points were selected as boundary conditions, and a computational fluid dynamics method was applied to evaluate its hemodynamic performance. The blood pressure distribution, blood flow fields, and high-wall-shear-stress zones in the centrifugal pump were determined as indicators for hemodynamic evaluation. Finally, standard in vitro hemolysis experiments were performed to test the blood compatibility of this centrifugal pump (n=3 blood samples). In addition, its blood compatibility was evaluated in the form of the normalized index of hemolysis (NIH).The pressure-flow curve of the centrifugal pump showed that the head pressure and flow of the centrifugal pump showed a mostly linear relationship within the whole working range. When the rotation speed of the centrifugal pump was 5,500 rpm, it achieved a hydraulic performance of 550 mmHg head pressure and 8 L/min output flow, which could meet the clinical needs of extracorporeal membrane oxygenation. Analysis of computational fluid dynamics data indicated that the centrifugal pump had excellent hemodynamic performance: even distribution of blood pressure in the pump, no blood flow stagnation zone or dead zone in the overall flow field, and secondary flows in the gap between the rotor and the volute that significantly reduced the volume of the low-blood-flow zone close to the impeller. There was no obvious high-shear-stress zone on the surface of the volute or the impeller, which will effectively reduce the risk of thrombosis. In vitro hemolysis experiments indicated that the centrifugal pump had excellent blood biocompatibility, with a NIH =0.0125±0.0022 g/100 L.The STM CP-24 I centrifugal pump has excellent hydraulic performance, a reasonable design of the hemodynamic structure of the blood pump, and excellent blood compatibility. Therefore, it can meet clinical needs.
关键词 ：
Centrifugal pump Centrifugal pump hemodynamics hemodynamics hemolysis hemolysis normalized index of hemolysis (NIH) normalized index of hemolysis (NIH)
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| GB/T 7714 | Fu Minrui , Liu Gang , Wang Weining et al. Hemodynamic evaluation and in vitro hemolysis evaluation of a novel centrifugal pump for extracorporeal membrane oxygenation. [J]. | Annals of translational medicine , 2021 , 9 (8) : 679 . |
| MLA | Fu Minrui et al. "Hemodynamic evaluation and in vitro hemolysis evaluation of a novel centrifugal pump for extracorporeal membrane oxygenation." . | Annals of translational medicine 9 . 8 (2021) : 679 . |
| APA | Fu Minrui , Liu Gang , Wang Weining , Gao Bin , Ji Bingyang , Chang Yu et al. Hemodynamic evaluation and in vitro hemolysis evaluation of a novel centrifugal pump for extracorporeal membrane oxygenation. . | Annals of translational medicine , 2021 , 9 (8) , 679 . |
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摘要 ：
Heart failure is one kind of cardiovascular disease with high risk and high incidence. As an effective treatment of heart failure, artificial heart is gradually used in clinical treatment. Blood compatibility is an important parameter or index of artificial heart, and how to evaluate it through hemodynamic design and in vitro hemolysis test is a research hotspot in the industry. This paper first reviews the research progress in hemodynamic optimization and in vitro hemolysis evaluation of artificial heart, and then introduces the research achievements and progress of the team in related fields. The hemodynamic performance of the blood pump optimized in this paper can meet the needs of use. The normalized index of hemolysis obtained by in standard vitro hemolysis test is less than 0.1 g/100 L, which has good hemolysis performance in vitro. The optimization method described in this paper is suitable for most of the development of blood pump and can provide reference for related research work.心力衰竭（心衰）是一种高危险、高发病率的心血管疾病。人工心脏作为心力衰竭的有效治疗手段正逐步应用于临床治疗中。血液相容性是人工心脏的重要参数或者指标，而如何通过血流动力学设计与体外溶血实验对其进行评价是业内的研究热点。本文首先对人工心脏血流动力学优化以及体外溶血评价方面的研究进展进行综述，之后介绍团队在相关领域的研究成果与进展。本文中所优化的血泵，血流动力学性能满足使用需求，体外溶血实验获得的溶血指数小于 0.1 g/100 L，有较好的体外溶血性能。本文所述的优化方法适合于大部分血泵的开发工作，能够为相关研究工作提供借鉴。.
关键词 ：
ventricular assist device ventricular assist device normalized index of hemolysis normalized index of hemolysis optimization optimization hemolysis hemolysis hemodynamics hemodynamics
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| GB/T 7714 | Fu Minrui , Gao Bin , Chang Yu et al. [Application of hemodynamic optimization in the design of artificial heart]. [J]. | Shengwu yixue gongchengxue zazhi , 2020 , 37 (6) : 1000-1011 . |
| MLA | Fu Minrui et al. "[Application of hemodynamic optimization in the design of artificial heart]." . | Shengwu yixue gongchengxue zazhi 37 . 6 (2020) : 1000-1011 . |
| APA | Fu Minrui , Gao Bin , Chang Yu , Liu Youjun . [Application of hemodynamic optimization in the design of artificial heart]. . | Shengwu yixue gongchengxue zazhi , 2020 , 37 (6) , 1000-1011 . |
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摘要 ：
心力衰竭(心衰)是一种高危险、高发病率的心血管疾病。人工心脏作为心力衰竭的有效治疗手段正逐步应用于临床治疗中。血液相容性是人工心脏的重要参数或者指标,而如何通过血流动力学设计与体外溶血实验对其进行评价是业内的研究热点。本文首先对人工心脏血流动力学优化以及体外溶血评价方面的研究进展进行综述,之后介绍团队在相关领域的研究成果与进展。本文中所优化的血泵,血流动力学性能满足使用需求,体外溶血实验获得的溶血指数小于0.1 g/100 L,有较好的体外溶血性能。本文所述的优化方法适合于大部分血泵的开发工作,能够为相关研究工作提供借鉴。
关键词 ：
优化 优化 归一化溶血指数 归一化溶血指数 心室辅助装置 心室辅助装置 溶血 溶血 血流动力学 血流动力学
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| GB/T 7714 | 符珉瑞 , 高斌 , 常宇 et al. 血流动力学优化在人工心脏设计中的应用 [J]. | 生物医学工程学杂志 , 2020 , 37 (6) : 1000-1011 . |
| MLA | 符珉瑞 et al. "血流动力学优化在人工心脏设计中的应用" . | 生物医学工程学杂志 37 . 6 (2020) : 1000-1011 . |
| APA | 符珉瑞 , 高斌 , 常宇 , 刘有军 . 血流动力学优化在人工心脏设计中的应用 . | 生物医学工程学杂志 , 2020 , 37 (6) , 1000-1011 . |
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摘要 ：
多级磁传动式机械辅助循环优化系统，属于生物医学工程领域。系统包括检测模块、决策模块和评价模块；检测模块中导入患MRI扫描图像，得到对应的心主动脉、胸部肋骨和体表的分割图像，将分割后的图像和测得的心排量和血压发送至决策模块，将血压波形发送至评价模块；决策模块通过系统基于多目标优化算法计算出多级磁传动机械辅助循环装置各级装置的尺寸；评价模块将量化后的数值基于加权平均算法计算出多级磁传动装置的评价值。具有高稳定性和便携性。
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| GB/T 7714 | 高斌 , 张万松 , 李仁鑫 et al. 多级磁传动式机械辅助循环优化系统 : CN202010283342.4[P]. | 2020-04-10 . |
| MLA | 高斌 et al. "多级磁传动式机械辅助循环优化系统" : CN202010283342.4. | 2020-04-10 . |
| APA | 高斌 , 张万松 , 李仁鑫 , 符珉瑞 , 常宇 . 多级磁传动式机械辅助循环优化系统 : CN202010283342.4. | 2020-04-10 . |
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摘要 ：
Excitation parameter preferences are key factors affecting the performance of magnetic frequency mixing detection. A uniform experimental design method was used to analyze this influence. Using fuzzy theory, a comprehensive model is established for evaluating the effect of magnetic frequency mixing. A polynomial is selected as the regression function to express explicitly the correlation between the excitation parameters and the frequency-mixing effect. The excitation parameters were then optimized using genetic algorithm. Magnetic frequency mixing experiments were conducted to measure the surface hardness of some ferromagnetic materials. Frequency mixing is further enhanced under the optimal settings, resulting in an improvement in the measurement sensitivity. The results of this study support the application of the magnetic frequency mixing technique in non-destructive testing.
关键词 ：
Excitation parameters Excitation parameters Magnetic frequency mixing technology Magnetic frequency mixing technology Regression statistical method Regression statistical method Surface hardness measurement Surface hardness measurement Uniform experimental design Uniform experimental design
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| GB/T 7714 | Chang, Yu , Jiao, Jingpin , Liu, Xiucheng et al. Application of Uniform Experimental Design in Optimizing Excitation Parameters for Magnetic Frequency Mixing Measurements [J]. | CHINESE JOURNAL OF MECHANICAL ENGINEERING , 2020 , 33 (1) . |
| MLA | Chang, Yu et al. "Application of Uniform Experimental Design in Optimizing Excitation Parameters for Magnetic Frequency Mixing Measurements" . | CHINESE JOURNAL OF MECHANICAL ENGINEERING 33 . 1 (2020) . |
| APA | Chang, Yu , Jiao, Jingpin , Liu, Xiucheng , Li, Guanghai , He, Cunfu , Wu, Bin . Application of Uniform Experimental Design in Optimizing Excitation Parameters for Magnetic Frequency Mixing Measurements . | CHINESE JOURNAL OF MECHANICAL ENGINEERING , 2020 , 33 (1) . |
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摘要 ：
Background and Objective: The series type of LVAD (i.e., BJUT-II VAD) is a novel left ventricular assist device, whose effects on the aortic valve remain unclear. Methods: The biomechanical effects of BJUT-II VAD on the aortic valve were investigated by using a fluidstructure interaction method. The geometric model of BJUT-II VAD was virtually implanted into the ascending aorta to generate the realistic flow pattern for the aortic valve (i.e., support). In addition, the biomechanical states of the aortic valve without BJUT-II VAD support was computed as control (i.e., control case). Results: Results demonstrated that the biomechanical effects of BJUT-II VAD were quite different from that resulting from traditional 'bypass LVAD.' Compared with those in the control case, BJUT-II VAD support could significantly reduce the stress load of the leaflet (maximum stress, 0.5 MPa in the control case vs. 0.12 MPa in the support case). Similarly, the rapid valve opening time (100 ms in the control case vs. 175 ms in the support case) and rapid valve closing time (50 ms in the control case vs. 150 ms in the support case) in the support case were obviously longer than those in the control case. Moreover, BJUT-II VAD support reduced retrograde blood flow during the diastolic phase and significantly changed the distribution of WSS of the leaflets. Conclusions: In summary, while unloading the left ventricle, BJUT-II VAD could provide beneficial biomechanical states for the aortic leaflets, thereby reducing the risk of aortic valve disease. © 2020
关键词 ：
Biomechanics Biomechanics Blood vessels Blood vessels Flow patterns Flow patterns Left ventricular assist devices Left ventricular assist devices Unloading Unloading
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| GB/T 7714 | Gao, Bin , Kang, Yizhou , Zhang, Qi et al. Biomechanical effects of the novel series LVAD on the aortic valve [J]. | Computer Methods and Programs in Biomedicine , 2020 , 197 . |
| MLA | Gao, Bin et al. "Biomechanical effects of the novel series LVAD on the aortic valve" . | Computer Methods and Programs in Biomedicine 197 (2020) . |
| APA | Gao, Bin , Kang, Yizhou , Zhang, Qi , Chang, Yu . Biomechanical effects of the novel series LVAD on the aortic valve . | Computer Methods and Programs in Biomedicine , 2020 , 197 . |
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摘要 ：
The role of pulsatile unloading in hemodynamic changes in intraventricular flow and ventricular wall stress remains unknown. In this study, a finite element model of the left ventricle (LV) is proposed to calculate the mechanical response. The constitutive model of the LV is composed of a quasi-incompressible transversely isotropic model and an active contraction of the myocardium model. Pulsatile unloading is provided by the left ventricular assist device (LVAD), which is implanted between the aortic root and aortic arch. Support models (constant speed and co-pulse) were utilized to study the effect of pulsatile unloading on intraventricular flow and ventricular stress. The result indicates that the formation time of the vortex increases under pulsatile unloading. The area rate of high time-averaged wall shear stress (TAWSS) increased after pulsatile unloading. The area of the high oscillatory shear index (OSI) region (OSI > 0.375) was calculated for heart failure, constant speed, and co-pulse (9.9 cm(2), 9.6 cm(2), and 9.2 cm(2), respectively). The maximum value of the stress that reflects the level of stretch declined after pulsatile unloading (66.4 kPa, 30.9 kPa, and 21.3 kPa, respectively). Besides, pulsatile unloading impacts the maximum value of thickness at the ventricular wall (-0.75 mm, -1 mm, and -1.25 mm, respectively). The change ratios of the thickness are 10%, 14%, and 17%, respectively. In conclusion, pulsatile unloading contributes to the distribution of intraventricular flow and the formation time of the vortex. Co-pulse support significantly reduces the maximum value of the ventricular wall stress and the area of high stress on the ventricular wall. (C) 2019 Elsevier Ltd. All rights reserved.
关键词 ：
Intraventricular flow Intraventricular flow Left ventricular assist devices Left ventricular assist devices Pulsatile unloading Pulsatile unloading Ventricular stress Ventricular stress
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| GB/T 7714 | Gu, Kaiyun , Guan, Zhiyuan , Chang, Yu et al. Hemodynamic effects of pulsatile unloading of left ventricular assist devices (LVAD) on intraventricular flow and ventricular stress [J]. | JOURNAL OF BIOMECHANICS , 2020 , 103 . |
| MLA | Gu, Kaiyun et al. "Hemodynamic effects of pulsatile unloading of left ventricular assist devices (LVAD) on intraventricular flow and ventricular stress" . | JOURNAL OF BIOMECHANICS 103 (2020) . |
| APA | Gu, Kaiyun , Guan, Zhiyuan , Chang, Yu , Gao, Bin , Ling, Yunpeng , Song, Zhiming et al. Hemodynamic effects of pulsatile unloading of left ventricular assist devices (LVAD) on intraventricular flow and ventricular stress . | JOURNAL OF BIOMECHANICS , 2020 , 103 . |
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摘要 ：
In order to identify the signature genes of tumorigenesis, the pattern-recognition method was used to analyze the gene methylation (ME) data which included only normal and cancer samples and was collected from the TCGA (The Cancer Genome Atlas) database. Here, we analyzed the DNA methylation profiles of the six types of cancer and the ME signature genes for each cancer were selected by means of a combination of correlation, students t-test and Elastic Net. Modeling by support vector machine, the accuracy of ME signature genes can be as high as 98 % for training set and as high as 97 % for the independent test set, the recognition accuracy of stage I is more than 97 % for training set and more than 98 % for test set. Then, the common signature genes and common pathways emerging in multiple cancers were obtained. A functional analysis of these signature genes indicates that the identified signatures have direct relationship with tumorigenesis and is very important for understanding the pathogenesis of cancer and the early therapy.
关键词 ：
Bioinformatics Bioinformatics Cancer genomics Cancer genomics Cancer occurrence Cancer occurrence Feature selection Feature selection TCGA TCGA
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| GB/T 7714 | Wang, Xuedong , Shang, Wenhui , Li, Xiaoqin et al. Methylation signature genes identification of cancers occurrence and pattern recognition [J]. | COMPUTATIONAL BIOLOGY AND CHEMISTRY , 2020 , 85 . |
| MLA | Wang, Xuedong et al. "Methylation signature genes identification of cancers occurrence and pattern recognition" . | COMPUTATIONAL BIOLOGY AND CHEMISTRY 85 (2020) . |
| APA | Wang, Xuedong , Shang, Wenhui , Li, Xiaoqin , Chang, Yu . Methylation signature genes identification of cancers occurrence and pattern recognition . | COMPUTATIONAL BIOLOGY AND CHEMISTRY , 2020 , 85 . |
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