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摘要 ：
利用共聚焦拉曼光谱技术,对人工心脏泵不同剪切应力下受到亚损伤的红细胞进行实验研究,验证拉曼光谱对红细胞亚损伤程度的评估能力,为血液损伤评价提供了一种新的思路。实验采集血红蛋白和红细胞的拉曼光谱标准谱图并进行对比分析,以确定红细胞谱图特征峰的归属。用血液剪切力试验平台对测试血样施加暴露时间为1 s,大小分别为0, 50, 100, 150, 200, 250和300 pa的剪切力。利用共聚焦拉曼仪器,在10倍长焦物镜,532 nm激光光源波长,积分时间10 s,积分次数2次,2.5 mW功率下采集剪切应力作用后的红细胞拉曼谱图。通过归一化的方法对比红细胞的拉曼谱图变化,评估红细胞亚损伤的程度,运...
关键词 ：
人工心脏 人工心脏 血液损伤 血液损伤 剪切应力 剪切应力 血红蛋白 血红蛋白 红细胞 红细胞 拉曼光谱 拉曼光谱
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| GB/T 7714 | 王金爽 , 付莹莹 , 符珉瑞 et al. 基于拉曼光谱方法研究不同剪切力下的红细胞亚损伤 [J]. | 光谱学与光谱分析 , 2021 , 41 (06) : 1811-1815 . |
| MLA | 王金爽 et al. "基于拉曼光谱方法研究不同剪切力下的红细胞亚损伤" . | 光谱学与光谱分析 41 . 06 (2021) : 1811-1815 . |
| APA | 王金爽 , 付莹莹 , 符珉瑞 , 高斌 , 郑大威 , 常宇 . 基于拉曼光谱方法研究不同剪切力下的红细胞亚损伤 . | 光谱学与光谱分析 , 2021 , 41 (06) , 1811-1815 . |
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摘要 ：
1.本外观设计产品的名称：无人机(槭树翅果)。2.本外观设计产品的用途：用于紧急救援背景下的物资投放。3.本外观设计产品的设计要点：在于形状与色彩的结合。4.最能表明设计要点的图片或照片：立体图。5.请求保护的外观设计包含色彩。
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| GB/T 7714 | 姬庆庆 , 李宁 , 王宇譞 et al. 无人机(槭树翅果) : CN202130165241.2[P]. | 2021-03-26 . |
| MLA | 姬庆庆 et al. "无人机(槭树翅果)" : CN202130165241.2. | 2021-03-26 . |
| APA | 姬庆庆 , 李宁 , 王宇譞 , 段泊池 , 常宇 , 孟佳晖 et al. 无人机(槭树翅果) : CN202130165241.2. | 2021-03-26 . |
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摘要 ：
多级磁传动式机械辅助循环优化系统，属于生物医学工程领域。系统包括检测模块、决策模块和评价模块；检测模块中导入患MRI扫描图像，得到对应的心主动脉、胸部肋骨和体表的分割图像，将分割后的图像和测得的心排量和血压发送至决策模块，将血压波形发送至评价模块；决策模块通过系统基于多目标优化算法计算出多级磁传动机械辅助循环装置各级装置的尺寸；评价模块将量化后的数值基于加权平均算法计算出多级磁传动装置的评价值。具有高稳定性和便携性。
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| GB/T 7714 | 高斌 , 张万松 , 李仁鑫 et al. 多级磁传动式机械辅助循环优化系统 : CN202010283342.4[P]. | 2020-04-10 . |
| MLA | 高斌 et al. "多级磁传动式机械辅助循环优化系统" : CN202010283342.4. | 2020-04-10 . |
| APA | 高斌 , 张万松 , 李仁鑫 , 符珉瑞 , 常宇 . 多级磁传动式机械辅助循环优化系统 : CN202010283342.4. | 2020-04-10 . |
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摘要 ：
In order to identify the signature genes of tumorigenesis, the pattern-recognition method was used to analyze the gene methylation (ME) data which included only normal and cancer samples and was collected from the TCGA (The Cancer Genome Atlas) database. Here, we analyzed the DNA methylation profiles of the six types of cancer and the ME signature genes for each cancer were selected by means of a combination of correlation, students t-test and Elastic Net. Modeling by support vector machine, the accuracy of ME signature genes can be as high as 98 % for training set and as high as 97 % for the independent test set, the recognition accuracy of stage I is more than 97 % for training set and more than 98 % for test set. Then, the common signature genes and common pathways emerging in multiple cancers were obtained. A functional analysis of these signature genes indicates that the identified signatures have direct relationship with tumorigenesis and is very important for understanding the pathogenesis of cancer and the early therapy.
关键词 ：
Bioinformatics Bioinformatics Cancer genomics Cancer genomics Cancer occurrence Cancer occurrence Feature selection Feature selection TCGA TCGA
引用：
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| GB/T 7714 | Wang, Xuedong , Shang, Wenhui , Li, Xiaoqin et al. Methylation signature genes identification of cancers occurrence and pattern recognition [J]. | COMPUTATIONAL BIOLOGY AND CHEMISTRY , 2020 , 85 . |
| MLA | Wang, Xuedong et al. "Methylation signature genes identification of cancers occurrence and pattern recognition" . | COMPUTATIONAL BIOLOGY AND CHEMISTRY 85 (2020) . |
| APA | Wang, Xuedong , Shang, Wenhui , Li, Xiaoqin , Chang, Yu . Methylation signature genes identification of cancers occurrence and pattern recognition . | COMPUTATIONAL BIOLOGY AND CHEMISTRY , 2020 , 85 . |
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摘要 ：
The role of pulsatile unloading in hemodynamic changes in intraventricular flow and ventricular wall stress remains unknown. In this study, a finite element model of the left ventricle (LV) is proposed to calculate the mechanical response. The constitutive model of the LV is composed of a quasi-incompressible transversely isotropic model and an active contraction of the myocardium model. Pulsatile unloading is provided by the left ventricular assist device (LVAD), which is implanted between the aortic root and aortic arch. Support models (constant speed and co-pulse) were utilized to study the effect of pulsatile unloading on intraventricular flow and ventricular stress. The result indicates that the formation time of the vortex increases under pulsatile unloading. The area rate of high time-averaged wall shear stress (TAWSS) increased after pulsatile unloading. The area of the high oscillatory shear index (OSI) region (OSI > 0.375) was calculated for heart failure, constant speed, and co-pulse (9.9 cm(2), 9.6 cm(2), and 9.2 cm(2), respectively). The maximum value of the stress that reflects the level of stretch declined after pulsatile unloading (66.4 kPa, 30.9 kPa, and 21.3 kPa, respectively). Besides, pulsatile unloading impacts the maximum value of thickness at the ventricular wall (-0.75 mm, -1 mm, and -1.25 mm, respectively). The change ratios of the thickness are 10%, 14%, and 17%, respectively. In conclusion, pulsatile unloading contributes to the distribution of intraventricular flow and the formation time of the vortex. Co-pulse support significantly reduces the maximum value of the ventricular wall stress and the area of high stress on the ventricular wall. (C) 2019 Elsevier Ltd. All rights reserved.
关键词 ：
Intraventricular flow Intraventricular flow Left ventricular assist devices Left ventricular assist devices Pulsatile unloading Pulsatile unloading Ventricular stress Ventricular stress
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| GB/T 7714 | Gu, Kaiyun , Guan, Zhiyuan , Chang, Yu et al. Hemodynamic effects of pulsatile unloading of left ventricular assist devices (LVAD) on intraventricular flow and ventricular stress [J]. | JOURNAL OF BIOMECHANICS , 2020 , 103 . |
| MLA | Gu, Kaiyun et al. "Hemodynamic effects of pulsatile unloading of left ventricular assist devices (LVAD) on intraventricular flow and ventricular stress" . | JOURNAL OF BIOMECHANICS 103 (2020) . |
| APA | Gu, Kaiyun , Guan, Zhiyuan , Chang, Yu , Gao, Bin , Ling, Yunpeng , Song, Zhiming et al. Hemodynamic effects of pulsatile unloading of left ventricular assist devices (LVAD) on intraventricular flow and ventricular stress . | JOURNAL OF BIOMECHANICS , 2020 , 103 . |
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摘要 ：
Excitation parameter preferences are key factors affecting the performance of magnetic frequency mixing detection. A uniform experimental design method was used to analyze this influence. Using fuzzy theory, a comprehensive model is established for evaluating the effect of magnetic frequency mixing. A polynomial is selected as the regression function to express explicitly the correlation between the excitation parameters and the frequency-mixing effect. The excitation parameters were then optimized using genetic algorithm. Magnetic frequency mixing experiments were conducted to measure the surface hardness of some ferromagnetic materials. Frequency mixing is further enhanced under the optimal settings, resulting in an improvement in the measurement sensitivity. The results of this study support the application of the magnetic frequency mixing technique in non-destructive testing.
关键词 ：
Regression statistical method Regression statistical method Uniform experimental design Uniform experimental design Magnetic frequency mixing technology Magnetic frequency mixing technology Surface hardness measurement Surface hardness measurement Excitation parameters Excitation parameters
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| GB/T 7714 | Chang, Yu , Jiao, Jingpin , Liu, Xiucheng et al. Application of Uniform Experimental Design in Optimizing Excitation Parameters for Magnetic Frequency Mixing Measurements [J]. | CHINESE JOURNAL OF MECHANICAL ENGINEERING , 2020 , 33 (1) . |
| MLA | Chang, Yu et al. "Application of Uniform Experimental Design in Optimizing Excitation Parameters for Magnetic Frequency Mixing Measurements" . | CHINESE JOURNAL OF MECHANICAL ENGINEERING 33 . 1 (2020) . |
| APA | Chang, Yu , Jiao, Jingpin , Liu, Xiucheng , Li, Guanghai , He, Cunfu , Wu, Bin . Application of Uniform Experimental Design in Optimizing Excitation Parameters for Magnetic Frequency Mixing Measurements . | CHINESE JOURNAL OF MECHANICAL ENGINEERING , 2020 , 33 (1) . |
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摘要 ：
The magnetic frequency mixing method was investigated for fatigue damage evaluation of medium carbon steel. Two types of magnetic signal, the magnetic flux density and the tangential magnetic field, are detected and analyzed. Two parameters, the magnetic frequency mixing factor and the power law coefficient, are proposed for magnetic frequency mixing effect characterization. On-line and off-line magnetic frequency mixing experiments were performed on specimens with various degrees of fatigue. Experimental results show that the two parameters changed along with the fatigue cycles with monotonic linear regularity and both parameters can be used for fatigue damage evaluation of medium carbon steel.
关键词 ：
Power law coefficient Power law coefficient Ferromagnetic material Ferromagnetic material Fatigue Fatigue Hysteresis nonlinearity Hysteresis nonlinearity Magnetic frequency mixing technology Magnetic frequency mixing technology
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| GB/T 7714 | Chang, Yu , Jiao, Jingpin , Liu, Xiucheng et al. Nondestructive evaluation of fatigue in ferromagnetic material using magnetic frequency mixing technology [J]. | NDT & E INTERNATIONAL , 2020 , 111 . |
| MLA | Chang, Yu et al. "Nondestructive evaluation of fatigue in ferromagnetic material using magnetic frequency mixing technology" . | NDT & E INTERNATIONAL 111 (2020) . |
| APA | Chang, Yu , Jiao, Jingpin , Liu, Xiucheng , Li, Guanghai , He, Cunfu , Wu, Bin . Nondestructive evaluation of fatigue in ferromagnetic material using magnetic frequency mixing technology . | NDT & E INTERNATIONAL , 2020 , 111 . |
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摘要 ：
多级磁传动式机械辅助循环优化系统，属于生物医学工程领域。系统包括检测模块、决策模块和评价模块；检测模块中导入患MRI扫描图像，得到对应的心主动脉、胸部肋骨和体表的分割图像，将分割后的图像和测得的心排量和血压发送至决策模块，将血压波形发送至评价模块；决策模块通过系统基于多目标优化算法计算出多级磁传动机械辅助循环装置各级装置的尺寸；评价模块将量化后的数值基于加权平均算法计算出多级磁传动装置的评价值。具有高稳定性和便携性。
引用：
复制并粘贴一种已设定好的引用格式，或利用其中一个链接导入到文献管理软件中。
| GB/T 7714 | 高斌 , 张万松 , 李仁鑫 et al. 多级磁传动式机械辅助循环优化系统 : CN202010283342.4[P]. | 2020-04-10 . |
| MLA | 高斌 et al. "多级磁传动式机械辅助循环优化系统" : CN202010283342.4. | 2020-04-10 . |
| APA | 高斌 , 张万松 , 李仁鑫 , 符珉瑞 , 常宇 . 多级磁传动式机械辅助循环优化系统 : CN202010283342.4. | 2020-04-10 . |
| 导入链接 | NoteExpress RIS BibTex |
摘要 ：
一种人工心脏出口管道旋动吻合接头，属于生物医学工程领域。包括支撑部、连接接头；支撑部、连接接头为一个整体；支撑部为长管状结构侧壁敞口弧的一部分，支撑部对应长管状结构侧壁的中心弧度为60°‑120°，支撑部用于贴合在连接血管的外侧面；连接接头整体为管状结构，用于连接人工心脏输出管，连接接头管状端口通过斜旋的方式与支撑部的管状结构侧壁连接连通在一起，支撑部管状结构的中心轴与连接接头的中心轴不共面且之间有一距离，且上述两中心轴之间具有夹角θ小于90°，上述两中心轴之间的距离小于等于连接接头管状结构半径的30％。通过调整两中心轴的距离以及两中心轴的夹角的角度，改变人工心脏血流流向，形成旋动血流。
引用：
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| GB/T 7714 | 高斌 , 张琪 , 马鑫蕊 et al. 一种人工心脏出口管道旋动吻合接头 : CN201910974755.4[P]. | 2019-10-14 . |
| MLA | 高斌 et al. "一种人工心脏出口管道旋动吻合接头" : CN201910974755.4. | 2019-10-14 . |
| APA | 高斌 , 张琪 , 马鑫蕊 , 常宇 . 一种人工心脏出口管道旋动吻合接头 : CN201910974755.4. | 2019-10-14 . |
| 导入链接 | NoteExpress RIS BibTex |
摘要 ：
一种人工心脏出口管道旋动吻合接头，属于生物医学工程领域。包括支撑部、连接接头；支撑部、连接接头为一个整体；支撑部为长管状结构侧壁敞口弧的一部分，支撑部对应长管状结构侧壁的中心弧度为60°‑120°，支撑部用于贴合在连接血管的外侧面；连接接头整体为管状结构，用于连接人工心脏输出管，连接接头管状端口通过斜旋的方式与支撑部的管状结构侧壁连接连通在一起，支撑部管状结构的中心轴与连接接头的中心轴不共面且之间有一距离，且上述两中心轴之间具有夹角θ小于90°，上述两中心轴之间的距离小于等于连接接头管状结构半径的30％。通过调整两中心轴的距离以及两中心轴的夹角的角度，改变人工心脏血流流向，形成旋动血流。
引用：
复制并粘贴一种已设定好的引用格式，或利用其中一个链接导入到文献管理软件中。
| GB/T 7714 | 高斌 , 张琪 , 马鑫蕊 et al. 一种人工心脏出口管道旋动吻合接头 : CN201921719040.6[P]. | 2019-10-14 . |
| MLA | 高斌 et al. "一种人工心脏出口管道旋动吻合接头" : CN201921719040.6. | 2019-10-14 . |
| APA | 高斌 , 张琪 , 马鑫蕊 , 常宇 . 一种人工心脏出口管道旋动吻合接头 : CN201921719040.6. | 2019-10-14 . |
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