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学者姓名：王秀红
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摘要 ：
Hollow core anti-resonant fiber (HARE) has found a handful applications in optical communications, nonlinear optics and high power delivery. The intrinsic property of the fiber also renders it an ideal candidate for biosensing, which has not been explored intensively. Herein, we demonstrate an optical fiber sensing platform, taking advantages of the state-of-the-art HARP technology and superior physicochemical properties of 2D material black phosphorus, for ultra-sensitive detection of bisphenol A (BPA) in blood and environmental samples. The specially designed HARP can not only achieve broadband transmission of light, but also confine light in the low refractive-index liquid core, ensuring maximum overlap of light and liquid core. Modification of the inner surface of HARP with 2D black phosphorus nanoflakes functionalized with fluorescently labeled BPA-specific aptamer provides a smart sensing interface enabling highly selective detection of BPA via measuring the fluorescence. The limit of detection is 1.69pM, which is more than two orders of magnitude enhancement compared to the conventional plate assay. The proposed assay is not interfered with the BPA analogues BPB and BPS. The long optical path with tight optical confinement greatly enhances the analyte-light interaction and improves the sensitivity of the sensing platform. The proposed sensing platform can be further developed for versatile applications.
关键词 ：
Aptamer Aptamer Bisphenol A Bisphenol A Black phosphorus Black phosphorus Hollow core anti-resonant fiber Hollow core anti-resonant fiber Sensor Sensor
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| GB/T 7714 | Qiao, Pengfei , Wang, Xiu-Hong , Gao, Shoufei et al. Integration of black phosphorus and hollow-core anti-resonant fiber enables two-order magnitude enhancement of sensitivity for bisphenol A detection [J]. | BIOSENSORS & BIOELECTRONICS , 2020 , 149 . |
| MLA | Qiao, Pengfei et al. "Integration of black phosphorus and hollow-core anti-resonant fiber enables two-order magnitude enhancement of sensitivity for bisphenol A detection" . | BIOSENSORS & BIOELECTRONICS 149 (2020) . |
| APA | Qiao, Pengfei , Wang, Xiu-Hong , Gao, Shoufei , Yin, Xiaoyan , Wang, Yingying , Wang, Pu . Integration of black phosphorus and hollow-core anti-resonant fiber enables two-order magnitude enhancement of sensitivity for bisphenol A detection . | BIOSENSORS & BIOELECTRONICS , 2020 , 149 . |
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摘要 ：
Whispering gallery mode is a type of optical mode where photons move in a quasi-two-dimensional plane, and the total reflection occurs at the boundary of the microcavity without reflecting out of the cavity. This mode has a high Q value and small mode volume, and it is extremely sensitive to changes in the surrounding environment. A broadband fluorescence can be transformed into narrow-spectrum laser output by using the whispering gallery mode. In this paper, polystyrene microspheres doped with the dragon green fluorescent dye are used as whispering gallery mode optical microcavity. Through the phagocytosis of cells, the fluorescent microspheres reach inside cells and then are pumped by nanosecond pulsed laser to achieve the output of whispering gallery mode laser in cells. In comparison with the laser output in the pure-water environment, a redshift of the intracellular fluorescent microsphere whispering gallery mode resonance emission can be observed, and the redshift is related to cell type; therefore, it can be used for unlabeled identification of cell type. © 2020, Chinese Lasers Press. All right reserved.
关键词 ：
Antigen-antibody reactions Antigen-antibody reactions Biotechnology Biotechnology Cells Cells Cytology Cytology Fluorescence Fluorescence Microcavities Microcavities Microspheres Microspheres Molecular biology Molecular biology Optical pumping Optical pumping Optical resonators Optical resonators Polystyrenes Polystyrenes Pulsed lasers Pulsed lasers Red Shift Red Shift Ultrafast lasers Ultrafast lasers Whispering gallery modes Whispering gallery modes
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| GB/T 7714 | Wang, Yaping , Wang, Xiuhong , Wang, Pu . Identifying Single Cell Types via Whispering Gallery Mode Optical Microcavities [J]. | Chinese Journal of Lasers , 2020 , 47 (2) . |
| MLA | Wang, Yaping et al. "Identifying Single Cell Types via Whispering Gallery Mode Optical Microcavities" . | Chinese Journal of Lasers 47 . 2 (2020) . |
| APA | Wang, Yaping , Wang, Xiuhong , Wang, Pu . Identifying Single Cell Types via Whispering Gallery Mode Optical Microcavities . | Chinese Journal of Lasers , 2020 , 47 (2) . |
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摘要 ：
Photoacoustic imaging, a novel biomedical imaging technique that combines the advantages of optical imaging and acoustic imaging, offers high-resolution biological tissue imaging to facilitate the observation of deeper imaging sites. In other words, it breaks the 'soft limit' of conventional optical bioimaging techniques. However, many diseases, especially in the early stage, present no obvious photoacoustic contrast; therefore, it is crucial to identify effective exogenous photoacoustic contrast agents. Here we introduce a novel two-dimensional material, antimonene nanoflakes (AMNFs), which demonstrates great optical absorption from 300 nm to 900 nm as well as excellent photothermal conversion efficiency and photoacoustic performance. This material is expected to be useful as a contrast agent, helping to achieve excellent photoacoustic imaging of ultra-small tumors in vivo. © 2020, Chinese Lasers Press. All right reserved.
关键词 ：
Light absorption Light absorption Medical imaging Medical imaging Photoacoustic effect Photoacoustic effect Tumors Tumors
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| GB/T 7714 | Yu, Jingwen , Wang, Xiuhong , Feng, Jinchao et al. Antimonene Nanoflakes as a Photoacoustic Imaging Contrast Agent for Tumor in vivo Imaging [J]. | Chinese Journal of Lasers , 2020 , 47 (2) . |
| MLA | Yu, Jingwen et al. "Antimonene Nanoflakes as a Photoacoustic Imaging Contrast Agent for Tumor in vivo Imaging" . | Chinese Journal of Lasers 47 . 2 (2020) . |
| APA | Yu, Jingwen , Wang, Xiuhong , Feng, Jinchao , Zhang, Na , Wang, Pu . Antimonene Nanoflakes as a Photoacoustic Imaging Contrast Agent for Tumor in vivo Imaging . | Chinese Journal of Lasers , 2020 , 47 (2) . |
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摘要 ：
Photoacoustic imaging (PAI) has evolved to a stage that high-performance exogeneous contrast agents are urgently needed for imminent biomedical and clinical applications. Given that a material meets the basic criteria of efficient photoacoustic conversion, high biocompatibility, and fast excretion, great effort has been devoted to evaluating various materials for developing advantageous contrast agents to explore the full potentials of PAI. One focus is through modification of the current agents to boost their PA performance; whilst the other focus is to develop novel agents. Antimonene (AM) has emerged as a promising candidate for next generation of electronics among 2D materials due to its outstanding properties. Herein, it is reported that liquid-phase exfoliated antimonene exhibits extraordinary photoacoustic performance, which is not only more advantageous than other 2D materials, such as black phosphorus, graphene oxide, and transition metal dichalcogenides, but also superior to the commonly used PA contrast agents, such as ICG and gold nanorods. An insight analysis reveals that the unique thermal property of AM, including intrinsic low thermal conductivity and the morphology-related high interfacial thermal conductivity, might interpret the high photothermal conversion efficiency, and thus the excellent photoacoustic performance. The prodigious performance allows sensitive monitoring of intracellular events and high-quality in vivo tumor imaging.
关键词 ：
2D materials 2D materials antimonene nanoflakes antimonene nanoflakes gold nanorods gold nanorods in vivo imaging in vivo imaging photoacoustic imaging photoacoustic imaging
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| GB/T 7714 | Yu, Jingwen , Wang, Xiu-Hong , Feng, Jinchao et al. Antimonene Nanoflakes: Extraordinary Photoacoustic Performance for High-Contrast Imaging of Small Volume Tumors [J]. | ADVANCED HEALTHCARE MATERIALS , 2019 , 8 (17) . |
| MLA | Yu, Jingwen et al. "Antimonene Nanoflakes: Extraordinary Photoacoustic Performance for High-Contrast Imaging of Small Volume Tumors" . | ADVANCED HEALTHCARE MATERIALS 8 . 17 (2019) . |
| APA | Yu, Jingwen , Wang, Xiu-Hong , Feng, Jinchao , Meng, Xiaotong , Bu, Xiangbao , Li, Yang et al. Antimonene Nanoflakes: Extraordinary Photoacoustic Performance for High-Contrast Imaging of Small Volume Tumors . | ADVANCED HEALTHCARE MATERIALS , 2019 , 8 (17) . |
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摘要 ：
When the core size of a holey microstructural fiber is close to the wavelength, the light propagation in the core is greatly enhanced and a strong evanescent field is produced around the core. A new air suspended core microstructural fiber with the core diameter of only 2 μm is reported. The air suspended core fiber fabricated by sheet-stacking method has large evanescent field and the unit structure with micrometer-size holes. The air suspended core fiber, whose loss is 0.16 dB/cm at the wavelength of 532 nm, is very suitable for sensing detection of biochemical substances. Using the air suspended core fiber as sensing probe, we establish a simple fluorescence detection system combining with laser technology, and detect the fluorescence properties of bioluminescent labeling material CdTe/CdS/ZnS quantum dots with this system. The limit of the fluorescence quantum dots detected by this system is about 1 nmol/L (corresponds to 3.78×10 7 quantum dots), which indicates that this system has the properties of high sensitivity and rapid detection speed. The fluorescence detection system based on the air suspended core microstructural fiber provides a new method and idea for the sensitive detection of biomaterials marked by quantum dots. © 2018, Chinese Lasers Press. All right reserved.
关键词 ：
Fluorescence Fluorescence Semiconductor quantum dots Semiconductor quantum dots Evanescent fields Evanescent fields Cadmium telluride Cadmium telluride Fiber optics Fiber optics Optical fiber fabrication Optical fiber fabrication Quantum dot lasers Quantum dot lasers Optical fibers Optical fibers Nanocrystals Nanocrystals II-VI semiconductors II-VI semiconductors
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| GB/T 7714 | Zhang, Zhao , Wang, Xiuhong , Qiao, Pengfei et al. High Sensitivity Fluorescence Detection System Based on Air Suspended Core Microstructural Fiber [J]. | Chinese Journal of Lasers , 2018 , 45 (5) . |
| MLA | Zhang, Zhao et al. "High Sensitivity Fluorescence Detection System Based on Air Suspended Core Microstructural Fiber" . | Chinese Journal of Lasers 45 . 5 (2018) . |
| APA | Zhang, Zhao , Wang, Xiuhong , Qiao, Pengfei , Liu, Qianqian , Marion, Lang , Feng, Xian et al. High Sensitivity Fluorescence Detection System Based on Air Suspended Core Microstructural Fiber . | Chinese Journal of Lasers , 2018 , 45 (5) . |
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摘要 ：
Breast cancer is a type of heterogeneous disease, which manifests as different molecular subtypes due to the complex nature of tumour initiation, progression, and metastasis. Accurate identification of a breast cancer subtype plays crucial roles in breast cancer management. Herein, taking advantage of the efficient quenching properties of black phosphorus nanosheets (BPNSs), in combination with the high specificity of ssDNA (or RNA) aptamer, a fluorometric duplexed assay that is capable of the simultaneous detection of two tumour markers within one run is developed. When mixed with BPNSs, the fluorescence of both FAM and Cy3 labelled aptamers was quenched. The presence of different subtypes of breast cancer cells restored the FAM and Cy3 fluorescence in distinct patterns according to their intrinsic features. The proposed assay can precisely recognise label-free breast cancer subtypes, providing an efficient method for cell type identification and guidance for subsequent breast cancer treatment. The significance of the proposed study is two-fold. First, we provide a simple method for sensitive and specific tumour cell detection; secondly, and more importantly, the proposed dual assay allows precise recognition of tumour cells and thus opens a door for rapid characterization and sorting of a wide range of tumours without using expensive instruments.
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| GB/T 7714 | Yan, Wujuan , Wang, Xiu-Hong , Yu, Jingwen et al. Precise and label-free tumour cell recognition based on a black phosphorus nanoquenching platform [J]. | JOURNAL OF MATERIALS CHEMISTRY B , 2018 , 6 (35) : 5613-5620 . |
| MLA | Yan, Wujuan et al. "Precise and label-free tumour cell recognition based on a black phosphorus nanoquenching platform" . | JOURNAL OF MATERIALS CHEMISTRY B 6 . 35 (2018) : 5613-5620 . |
| APA | Yan, Wujuan , Wang, Xiu-Hong , Yu, Jingwen , Meng, Xiaotong , Qiao, Pengfei , Yin, Huabing et al. Precise and label-free tumour cell recognition based on a black phosphorus nanoquenching platform . | JOURNAL OF MATERIALS CHEMISTRY B , 2018 , 6 (35) , 5613-5620 . |
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摘要 ：
Black phosphorus (BP) has attracted much attention as a new member of 2D materials due to its unique electronic and optical properties and a wide range of promising applications. Here, for the first time, we report the photoluminescence lifetime of BP nanomaterial and its applications as an efficient agent for live cell imaging. With a lateral size of similar to 35 nm and a thickness of similar to 6 nm, the fabricated BP nanoparticles (BPNPs) exhibited a unique photoluminescent (PL) emission at similar to 690 nm. The photoluminescence lifetime (PLT) of BPNPs was determined to be 110.5 ps. Coating a layer of mesoporous silica on the surface of BPNPs (BPNPs@mSiO(2)) extended the lifetime to 267 ps, suggesting a change in the microenvironment. The lifetime was also influenced by ionic strength and intracellular microenvironment, which implies BPNPs as valuable probes for sensing variations in the microenvironment. Live cell imaging was achieved via directly probing the photoluminescence intensity or the photoluminescence lifetime. Our findings are significant, implying that BPNPs can be of large value in sensing variations of the cellular microenvironment and in probing cells with distinct cytosolic contents. This research leads to promising prospects for BPNPs in multiple biomedical applications.
关键词 ：
black phosphorus black phosphorus FLIM FLIM photoluminescence photoluminescence Raman mapping Raman mapping silicon dioxide coating silicon dioxide coating
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| GB/T 7714 | Meng, Xiaotong , Wang, Xiuhong , Cheng, Zhaochen et al. Photoluminescence Lifetime of Black Phosphorus Nanoparticles and Their Applications in Live Cell Imaging [J]. | ACS APPLIED MATERIALS & INTERFACES , 2018 , 10 (37) : 31136-31145 . |
| MLA | Meng, Xiaotong et al. "Photoluminescence Lifetime of Black Phosphorus Nanoparticles and Their Applications in Live Cell Imaging" . | ACS APPLIED MATERIALS & INTERFACES 10 . 37 (2018) : 31136-31145 . |
| APA | Meng, Xiaotong , Wang, Xiuhong , Cheng, Zhaochen , Tian, Nan , Lang, Marion C. , Yan, Wujuan et al. Photoluminescence Lifetime of Black Phosphorus Nanoparticles and Their Applications in Live Cell Imaging . | ACS APPLIED MATERIALS & INTERFACES , 2018 , 10 (37) , 31136-31145 . |
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摘要 ：
Black phosphorus (BP) nanosheets can quench the fluorescence of a fluorescent dye, and based on this property, the deoxyribonucleic acid(DNA) aptamer which can specifically recognize the human breast cancer cells MCF7 are synthesized and labeled with 5-carboxyfluorescein (FAM). When the DNA aptamer is mixed with BP nanosheets, its fluorescence is quenched. However, in the presence of MCF7 cells, the DNA aptamer can recognize the MCF7 cells and interact with these cells, and the disassociation of DNA aptamer from BP nanosheets occurs and then the restoration of fluorescence is realized. The fluorescence intensity shows the linear relationship with the number of cancer cells. The experimental results indicate that it is highly efficient, specific and sensitive to use BP nanosheets for detecting breast cancer cells and this method can be applied in the detection of other kinds of cancer cells. © 2018, Chinese Lasers Press. All right reserved.
关键词 ：
Black Phosphorus Black Phosphorus Cells Cells Cytology Cytology Diseases Diseases DNA DNA Fluorescence Fluorescence Fluorescence quenching Fluorescence quenching Nanosheets Nanosheets Phosphorus Phosphorus Quenching Quenching
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| GB/T 7714 | Yan, Wujuan , Wang, Xiuhong , Yao, Qian et al. Detection of Cancer Cells Based on Fluorescence Quenching Property of Black Phosphorus [J]. | Chinese Journal of Lasers , 2018 , 45 (2) . |
| MLA | Yan, Wujuan et al. "Detection of Cancer Cells Based on Fluorescence Quenching Property of Black Phosphorus" . | Chinese Journal of Lasers 45 . 2 (2018) . |
| APA | Yan, Wujuan , Wang, Xiuhong , Yao, Qian , Qiao, Pengfei , Lang, Marion C . Detection of Cancer Cells Based on Fluorescence Quenching Property of Black Phosphorus . | Chinese Journal of Lasers , 2018 , 45 (2) . |
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摘要 ：
Antibody therapy is a type of immunotherapy that uses monoclonal antibodies (mAbs) to specifically bind to target cells to fight cancer. These mAbs have been conjugated with a number of nanocarriers to realize the targeted delivery of chemotherapeutics. Previous data indicate that the conjugation of a mAb to a nanocarrier promoted the faster internalization (endocytosis) of the nanoconjugates. In this study, we report that the crosslinking of Rituxan, an anti-lymphoma mAb, with silver nanoparticles prevented Rituxan from entering cells and prolonged drug/cell interaction. This finding was confirmed by both imaging flow cytometric and laser scanning confocal microscopic analyses of the fluorescently labeled nanoconjugates and cells. Furthermore, nanoconjugated Rituxan resulted in the enhanced capping of CD20 molecules on the cell membrane. We were able to show that the prolonged drug/cell interaction and enhanced capping directly contributed towards improved therapeutic efficiency. This represents a significant finding indicating that the nanocarrier served not only as a simple platform for targeted delivery, but also markedly altered the antibody performance at the molecular level and mediated key biological functions. The nanoconjugates also served as a Raman probe to specifically detect single live lymphoma cells with high sensitivity via surface-enhanced Raman scattering (SERS). Via integrating the single-cell level detection sensitivity of SERS with targeted and enhanced depletion ability, this nanoconjugate can be applied as a promising tool in lymphoma theranostics.
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| GB/T 7714 | Yao, Qian , Cao, Fei , Lang, Marion et al. Rituxan nanoconjugation prolongs drug/cell interaction and enables simultaneous depletion and enhanced Raman detection of lymphoma cells [J]. | JOURNAL OF MATERIALS CHEMISTRY B , 2017 , 5 (26) : 5165-5175 . |
| MLA | Yao, Qian et al. "Rituxan nanoconjugation prolongs drug/cell interaction and enables simultaneous depletion and enhanced Raman detection of lymphoma cells" . | JOURNAL OF MATERIALS CHEMISTRY B 5 . 26 (2017) : 5165-5175 . |
| APA | Yao, Qian , Cao, Fei , Lang, Marion , Feng, Chao , Meng, Xiaotong , Zhang, Yongzhe et al. Rituxan nanoconjugation prolongs drug/cell interaction and enables simultaneous depletion and enhanced Raman detection of lymphoma cells . | JOURNAL OF MATERIALS CHEMISTRY B , 2017 , 5 (26) , 5165-5175 . |
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| GB/T 7714 | Yang, Tieshan , Cao, Fei , Liu, Qianqian et al. Silver nanoparticles inhibit hypoxia inducible factor function and cancer cell growth [J]. | NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE , 2016 , 12 (2) : 554-554 . |
| MLA | Yang, Tieshan et al. "Silver nanoparticles inhibit hypoxia inducible factor function and cancer cell growth" . | NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 12 . 2 (2016) : 554-554 . |
| APA | Yang, Tieshan , Cao, Fei , Liu, Qianqian , Wang, Xiuhong . Silver nanoparticles inhibit hypoxia inducible factor function and cancer cell growth . | NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE , 2016 , 12 (2) , 554-554 . |
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