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学者姓名：张红胜
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摘要 ：
药理学线上线下混合式教学的思考与实践
关键词 ：
线上线下混合式教学 线上线下混合式教学 慕课 慕课 课程思政 课程思政 药理学 药理学
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| GB/T 7714 | 张红胜 , 科技资讯 . 药理学线上线下混合式教学的思考与实践 [J]. | 张红胜 , 2021 , 19 (5) : 155-158 . |
| MLA | 张红胜 等. "药理学线上线下混合式教学的思考与实践" . | 张红胜 19 . 5 (2021) : 155-158 . |
| APA | 张红胜 , 科技资讯 . 药理学线上线下混合式教学的思考与实践 . | 张红胜 , 2021 , 19 (5) , 155-158 . |
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摘要 ：
线上线下混合式教学成为实现大学教育教学新形态。结合药理学线上教学与传统线下课堂教学的特点,探讨了基于慕课异步SPOC课程的特点及其与传统教学模式相融合的混合式教学模式的探索,包括教学平台的选择、教学的组织和特点、教学的考核等,分析了线上线下混合式教学模式的新特点,旨在促进线上教学与传统教学在药理学课堂中的应用,为传统教学提供了新的活力。
关键词 ：
药理学 药理学 课程思政 课程思政 慕课 慕课 线上线下混合式教学 线上线下混合式教学
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| GB/T 7714 | 张红胜 . 药理学线上线下混合式教学的思考与实践 [J]. | 科技资讯 , 2021 , 19 (05) : 155-158 . |
| MLA | 张红胜 . "药理学线上线下混合式教学的思考与实践" . | 科技资讯 19 . 05 (2021) : 155-158 . |
| APA | 张红胜 . 药理学线上线下混合式教学的思考与实践 . | 科技资讯 , 2021 , 19 (05) , 155-158 . |
| 导入链接 | NoteExpress RIS BibTex |
摘要 ：
如何充分发掘药理学专业基础课程所蕴含的课程思政元素,将其融入日常教学,对实现三全育人,引导当代大学生建立正确人生观、价值观及职业观,具有重要的现实意义.本文主要从探索课程思政与药理学专业课程的有效融合教学范式,发挥立德树人和三全育人的重要作用.
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| GB/T 7714 | 张红胜 . 学科历史与学科前沿融入药理学课程思政的探索与实践 [J]. | 产业与科技论坛 , 2021 , 20 (10) : 153-154 . |
| MLA | 张红胜 . "学科历史与学科前沿融入药理学课程思政的探索与实践" . | 产业与科技论坛 20 . 10 (2021) : 153-154 . |
| APA | 张红胜 . 学科历史与学科前沿融入药理学课程思政的探索与实践 . | 产业与科技论坛 , 2021 , 20 (10) , 153-154 . |
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摘要 ：
课程思政是新时期高校教育新模式.如何充分发掘医学基础专业基础课程蕴含的课程思政元素,将其融入教学实践过程中,对实现三全育人,引导学生建立正确的人生观、价值观及职业观,具有重要的现实意义.通过对医学基础的课程思政元素和教案设计进行探索与实践,设计医学基础课程思政的切入点、思路.通过教学实践与教学反思,准确地把握思想政治教育的时机与方法.主要探索课程思政与医学基础课程的有效融合教学范式,发挥立德树人和三全育人的重要作用.
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| GB/T 7714 | 张红胜 , 王明连 . 研究生医学基础课程思政教学的探索与实践 [J]. | 教育教学论坛 , 2021 , (38) : 58-61 . |
| MLA | 张红胜 等. "研究生医学基础课程思政教学的探索与实践" . | 教育教学论坛 38 (2021) : 58-61 . |
| APA | 张红胜 , 王明连 . 研究生医学基础课程思政教学的探索与实践 . | 教育教学论坛 , 2021 , (38) , 58-61 . |
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摘要 ：
Cancer cells can metabolize glutamine to replenish TCA cycle intermediates for cell survival. Glutaminase (GLS1) is over-expressed in multiple cancers, including colorectal cancer (CRC). However, the role of GLS1 in colorectal cancer development has not yet fully elucidated. In this study, we found that GLS1 levels were significantly increased in CRC cells. Knockdown of GLS1 by shRNAs as well as GLS1 inhibitor BPTES decreased DLD1 and SW480 cell proliferation, colony formation and migration. Knockdown of GLS1 as well as BPTES induced reactive oxygen species (ROS) production, down-regulation of GSH/GSSG ratio, an decrease in Nrf2 protein expression and an increase in cytoplasmic Nrf2 protein expression in DLD1 and SW480 cells. Furthermore, Knockdown of GLS1 as well as BPTES inhibited autophagy pathway, antioxidant NAC and Nrf2 activator could reversed inhibition of GLS1-mediated an decrease in autophagic flux in DLD1 and SW480 cells. Depletion of GLS1-induced inhibition of DLD1 and SW480 CRC cell proliferation, colony formation and migration was reversed by autophagy inducer rapamycin. These results suggest that targeting GLS1 might be a new potential therapeutic target for the treatment of CRC.
关键词 ：
Autophagy Autophagy Colorectal cancer Colorectal cancer GLS1 GLS1 Redox Redox
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| GB/T 7714 | Liu, Hui-Yun , Zhang, Hong-Sheng , Liu, Min-Yao et al. GLS1 depletion inhibited colorectal cancer proliferation and migration via redox/Nrf2/autophagy-dependent pathway [J]. | ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS , 2021 , 708 . |
| MLA | Liu, Hui-Yun et al. "GLS1 depletion inhibited colorectal cancer proliferation and migration via redox/Nrf2/autophagy-dependent pathway" . | ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 708 (2021) . |
| APA | Liu, Hui-Yun , Zhang, Hong-Sheng , Liu, Min-Yao , Li, Hong-Ming , Wang, Xin-Yu , Wang, Miao . GLS1 depletion inhibited colorectal cancer proliferation and migration via redox/Nrf2/autophagy-dependent pathway . | ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS , 2021 , 708 . |
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摘要 ：
Road datasets are fundamental and imperative for traffic management and urban planning. Different high resolution optical remote sensing images are widely used for automatic road extraction but the results are usually limited to local scale and spectral confusions in barren and cropland, while accurate large-scale road extraction remains challenging. In this study, we incorporated medium resolution optical and SAR data, i.e., 10 meter resolution Sentinel-1 and Sentinel-2, for road extraction at a large scale and evaluated the contribution of different data sources. We developed a United U-Net (UU-Net) to fuse optical and SAR data for road extraction, which was trained and evaluated on a large-scale multisource road extraction dataset. The UU-Net achieved better accuracy than traditional deep convolutional networks with optical or SAR data alone, which obtained an average F1 of 0.5502 and an average IoU of 0.4021, outperforming in 160 out of 200 (80%) 0.5-by-0.5 degree evaluation grids. The results indicated that SAR contributes more to road extraction in barren land, while optical data contributes more to large slope areas. The road accuracy is positively related to elevation and urban percentage, which distributes higher in eastern China and lower in western. The road centerline from 10 m road showed comparable results with that from Open Street Map (OSM), indicating its promising applications to support large-scale urban transportation studies.
关键词 ：
Optical Optical OSM OSM Road Road SAR SAR U-Net U-Net
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| GB/T 7714 | Lin, Yinyi , Wan, Luoma , Zhang, Hongsheng et al. Leveraging optical and SAR data with a UU-Net for large-scale road extraction [J]. | INTERNATIONAL JOURNAL OF APPLIED EARTH OBSERVATION AND GEOINFORMATION , 2021 , 103 . |
| MLA | Lin, Yinyi et al. "Leveraging optical and SAR data with a UU-Net for large-scale road extraction" . | INTERNATIONAL JOURNAL OF APPLIED EARTH OBSERVATION AND GEOINFORMATION 103 (2021) . |
| APA | Lin, Yinyi , Wan, Luoma , Zhang, Hongsheng , Wei, Shan , Ma, Peifeng , Li, Yu et al. Leveraging optical and SAR data with a UU-Net for large-scale road extraction . | INTERNATIONAL JOURNAL OF APPLIED EARTH OBSERVATION AND GEOINFORMATION , 2021 , 103 . |
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摘要 ：
The COVID-19 pandemic has severely affected various aspects of life, at different levels and in different countries on almost every continent. In response, many countries have closed their borders and imposed lockdown policies, possibly bringing benefits to people's health with significantly less emission from air pollutants. Currently, most studies or reports are based on local observations at the city or country level. There remains a lack of systematic understanding of the impacts of different lockdown policies on the air quality from a global perspective. This study investigates the impacts of COVID-19 pandemic towards global air quality through examining global nitrogen dioxide (NO2) dynamics from satellite observations between 1 January and 30 April 2020. We used the Apriori algorithm, an unsupervised machine learning method, to investigate the association among confirmed cases of COVID-19, NO2 column density, and the lockdown policies in 187 countries. The findings based on weekly data revealed that countries with new cases adopted various lockdown policies to stop or prevent the virus from spreading whereas those without tended to adopt a wait-and-see attitude without enforcing lockdown policies. Interestingly, decreasing NO2 concentration due to lockdown was associated with international travel controls but not with public transport closure. Increasing NO2 concentration was associated with the "business as usual" strategy as evident from North America and Europe during the early days of COVID-19 outbreak (late January to early February 2020), as well as in recent days (in late April) after many countries have started to resume economic activities. This study enriches our understanding of the heterogeneous patterns of global associations among the COVID-19 spreading, lockdown policies and their environmental impacts on NO2 dynamics.
关键词 ：
Apriori Apriori Association rules Association rules Coronavirus Coronavirus COVID-19 COVID-19 Lockdown policies Lockdown policies NO(2) NO(2)
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| GB/T 7714 | Zhang Hongsheng , Lin Yinyi , Wei Shan et al. Global association between satellite-derived nitrogen dioxide (NO2) and lockdown policies under the COVID-19 pandemic. [J]. | The Science of the total environment , 2021 , 761 : 144148 . |
| MLA | Zhang Hongsheng et al. "Global association between satellite-derived nitrogen dioxide (NO2) and lockdown policies under the COVID-19 pandemic." . | The Science of the total environment 761 (2021) : 144148 . |
| APA | Zhang Hongsheng , Lin Yinyi , Wei Shan , Loo Becky P Y , Lai P C , Lam Yun Fat et al. Global association between satellite-derived nitrogen dioxide (NO2) and lockdown policies under the COVID-19 pandemic. . | The Science of the total environment , 2021 , 761 , 144148 . |
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摘要 ：
培养学生自主学习与创新能力是高等教育的重要任务.药理学课程内容烦琐以及概念抽象成为教学难点.在药理学教学过程中,引入FDA最新批准的新药研讨式教学作为创新性教学方法,将"以学生为中心"的教育理念渗透到药理学教学的全过程,提出了自主学习理念下的药理学混合教学策略.该方法提高了教学效果,提高了学生学习药理学的积极性,培养了学生自主学习能力和创新性思维能力,增强了学生科研兴趣,培养了学生的团队协作意识.
关键词 ：
新药药理 新药药理 药理学 药理学 教学改革 教学改革
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| GB/T 7714 | 张红胜 , 孙洪亮 , 刘慧云 . FDA批准的新药研讨式教学在药理学课堂的实践与探索 [J]. | 教育教学论坛 , 2020 , (34) : 264-266 . |
| MLA | 张红胜 et al. "FDA批准的新药研讨式教学在药理学课堂的实践与探索" . | 教育教学论坛 34 (2020) : 264-266 . |
| APA | 张红胜 , 孙洪亮 , 刘慧云 . FDA批准的新药研讨式教学在药理学课堂的实践与探索 . | 教育教学论坛 , 2020 , (34) , 264-266 . |
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摘要 ：
Aims: Colorectal cancer (CRC) is the fourth leading cause of cancer-related mortality worldwide. Over-expression of tetraspanin 8 (TSPAN8) is related to the development and progression of CRC. Whether TSPAN8 plays a role in the growth of colorectal cancer and its epigenetic mechanisms regulated by Lysine Specific Demethylase 1 (LSD1) are still unknown. Main methods: In this study, RT-PCR and western blotting were used to analyze the mRNA and protein expression, respectively; cell viability was assayed with MTS analysis; cell migration was measured with Trans-well analysis. Key findings: In the present study, the results indicated that the mRNA levels of LSD1 and TSPAN8 in CRC were significantly higher than that in corresponding adjacent non-tumor tissue. Down-regulation of LSD1 or TSPAN8 as well as LSD1 inhibitor Tranylcypromine hemisulfate inhibited the proliferation and migration of CRC cells, while over-expression of LSD1 exhibited opposite effects. LSD1 up-regulated TSPAN8 expression and reduced H3K9me2 occupancy on the TSPAN8 promoter in CRC cells. TSPAN8 promoted epithelial-mesenchymal transition (EMT) in CRC cells in LSD1-dependent manner. Significance: TSPAN8 may be considered as a promising biomarker for the diagnosis and prognosis in patients with CRC. Furthermore, TSPAN8 could be a novel therapeutic target and potent LSD1 inhibitors could be designed and developed in the treatment of CRC.
关键词 ：
Colorectal cancer Colorectal cancer EMT EMT H3K9me2 H3K9me2 LSD1 LSD1 TSPAN8 TSPAN8
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| GB/T 7714 | Zhang, Hong-Sheng , Liu, Hui-Yun , Zhou, Zhen et al. TSPAN8 promotes colorectal cancer cell growth and migration in LSD1-dependent manner [J]. | LIFE SCIENCES , 2020 , 241 . |
| MLA | Zhang, Hong-Sheng et al. "TSPAN8 promotes colorectal cancer cell growth and migration in LSD1-dependent manner" . | LIFE SCIENCES 241 (2020) . |
| APA | Zhang, Hong-Sheng , Liu, Hui-Yun , Zhou, Zhen , Sun, Hong-Liang , Liu, Min-Yao . TSPAN8 promotes colorectal cancer cell growth and migration in LSD1-dependent manner . | LIFE SCIENCES , 2020 , 241 . |
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摘要 ：
Breast cancer has the highest incidence and mortality in the female population. Forkhead box M1 (FOXM1) known as a transcription factor is upregulated and associated with poor prognosis in a variety of cancers. However, the molecular mechanisms of FOXM1 on breast cancer progression are poorly understood. In this study, we found that FOXM1 was up-regulated in breast cancer. FOXM1 promoted cell proliferation, clonal formation, and migration capacity in triple negative breast cancer by increasing transcriptional activity of YAP1. FOXM1 also maintained cell stemness via the Hippo pathway. The YAP1-TEAD binding inhibitor Verteporfin reduced the transcription level of OCT4 and NANOG but the Hippo pathway activator XMU-MP-1 could increase the transcription level of OCT4 and NANOG. In summary, our findings indicated that FOXM1 promoted breast cancer progression through the Hippo pathway, and it was suggested a new strategy to treat breast cancer.
关键词 ：
Breast cancer Breast cancer Cancer stemness Cancer stemness FOXM1 FOXM1 YAP1 YAP1
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| GB/T 7714 | Sun, Hong-Liang , Men, Jing-Rui , Liu, Hui-Yun et al. FOXM1 facilitates breast cancer cell stemness and migration in YAP1-dependent manner [J]. | ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS , 2020 , 685 . |
| MLA | Sun, Hong-Liang et al. "FOXM1 facilitates breast cancer cell stemness and migration in YAP1-dependent manner" . | ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 685 (2020) . |
| APA | Sun, Hong-Liang , Men, Jing-Rui , Liu, Hui-Yun , Liu, Min-Yao , Zhang, Hong-Sheng . FOXM1 facilitates breast cancer cell stemness and migration in YAP1-dependent manner . | ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS , 2020 , 685 . |
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