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学者姓名：张红胜
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摘要 ：
Colorectal cancer (CRC) has emerged as the third most prevalent and second deadliest cancer worldwide. Metabolic reprogramming is a key hallmark of cancer cells. Phosphoglycerate dehydrogenase (PHGDH) is over-expressed in multiple cancers, including CRC. Although the role of PHGDH in metabolism has been extensively investigated, its effects on CRC development remains to be elucidated. In the present study, it was demonstrated that PHGDH expression was significantly up-regulated in colorectal cancer. PHGDH expression was positively correlated with that of the aryl hydrocarbon receptor (AhR) and its target genes, CYP1A1 and CYP1B1, in CRC cells. Knockdown of PHGDH reduced AhR levels and activity, as well as the ratio of reduced to oxidized glutathione. The selective AhR antagonist stemregenin 1 induced cell death through reactive oxygen species-dependent autophagy in CRC cells. PHGDH knockdown induced CRC cell sensitivity to stemregenin 1 via the autophagy pathway. Our findings suggest that PHGDH modulates AhR signaling and the redox-dependent autophagy pathway in CRC, and that the combination of inhibition of both PHGDH and AhR may be a novel therapeutic strategy for CRC.
关键词 ：
AhR AhR PHGDH PHGDH autophagy autophagy colorectal cancer colorectal cancer
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| GB/T 7714 | Li, Hong-Ming , Li, Xiang , Xia, Ran et al. PHGDH knockdown increases sensitivity to SR1, an aryl hydrocarbon receptor antagonist, in colorectal cancer by activating the autophagy pathway [J]. | FEBS JOURNAL , 2024 , 291 (8) : 1780-1794 . |
| MLA | Li, Hong-Ming et al. "PHGDH knockdown increases sensitivity to SR1, an aryl hydrocarbon receptor antagonist, in colorectal cancer by activating the autophagy pathway" . | FEBS JOURNAL 291 . 8 (2024) : 1780-1794 . |
| APA | Li, Hong-Ming , Li, Xiang , Xia, Ran , Zhang, Xing , Jin, Tong-Zhao , Zhang, Hong-Sheng . PHGDH knockdown increases sensitivity to SR1, an aryl hydrocarbon receptor antagonist, in colorectal cancer by activating the autophagy pathway . | FEBS JOURNAL , 2024 , 291 (8) , 1780-1794 . |
| 导入链接 | NoteExpress RIS BibTex |
摘要 ：
The solute carrier (SLC) family, with more than 400 membrane -bound proteins, facilitates the transport of a wide array of substrates such as nutrients, ions, metabolites, and drugs across biological membranes. Amino acid transporters (AATs) are membrane transport proteins that mediate transfer of amino acids into and out of cells or cellular organelles. AATs participate in many important physiological functions including nutrient supply, metabolic transformation, energy homeostasis, redox regulation, and neurological regulation. Several AATs have been found to significantly impact the progression of human malignancies, and dysregulation of AATs results in metabolic reprogramming affecting tumor growth and progression. However, current clinical therapies that directly target AATs have not been developed. The purpose of this review is to highlight the structural and functional diversity of AATs, the molecular mechanisms in human diseases such as tumors, kidney diseases, and emerging therapeutic strategies for targeting AATs.
关键词 ：
targeted therapy targeted therapy cancer therapy cancer therapy SLC transporter SLC transporter amino acid transporter amino acid transporter
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| GB/T 7714 | Xia, Ran , Peng, Hai-Feng , Zhang, Xing et al. Comprehensive review of amino acid transporters as therapeutic targets [J]. | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2024 , 260 . |
| MLA | Xia, Ran et al. "Comprehensive review of amino acid transporters as therapeutic targets" . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 260 (2024) . |
| APA | Xia, Ran , Peng, Hai-Feng , Zhang, Xing , Zhang, Hong-Sheng . Comprehensive review of amino acid transporters as therapeutic targets . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2024 , 260 . |
| 导入链接 | NoteExpress RIS BibTex |
摘要 ：
Staphylococcus aureus (S. aureus) is a prevalent foodborne pathogen that could cause severe food poisoning. Thus, rapid, efficient, and ultrasensitive detection of S. aureus in food samples is urgently needed. Here, we report an efficient magnetic enrichment cascade single-step recombinase polymerase amplification (RPA)-CRISPR/Cas12a assay for the ultrasensitive detection of S. aureus. Magnetic beads (MBs) functionalized with S. aureus-specific antibodies were initially used for S. aureus enrichment from the complex matrix, with 98% capture efficiency in 5 min and 100 -fold sensitivity improvement compared with unenriched S. aureus. Next, a single-step RPACRISPR/Cas12a-based diagnostic system with optimized extraction-free bacteria lysis was constructed. This assay could detect as low as 1 copy/mu L (five copies/reaction) of extracted DNA template and 10 CFU/mL of S. aureus within 40 min. Furthermore, the assay could effectively detect S. aureus in real food samples such as lake water, orange juice, pork, and lettuce, with concordant results to qPCR assays. The proposed cascade signalamplification assay eliminates the need for lengthy bacterial culture and complex sample preparation steps. Hence, the proposed assay shows great application potential for rapid, efficient, and ultrasensitive detection of pathogens in real food samples.
关键词 ：
Staphylococcus aureus Staphylococcus aureus Bacteria lysis Bacteria lysis Single-step RPA-CRISPR/Cas12a Single-step RPA-CRISPR/Cas12a Magnetic enrichment Magnetic enrichment
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| GB/T 7714 | Ma, Yujie , Wei, Hongjuan , Wang, Yunxiang et al. Efficient magnetic enrichment cascade single-step RPA-CRISPR/Cas12a assay for rapid and ultrasensitive detection of Staphylococcus aureus in food samples [J]. | JOURNAL OF HAZARDOUS MATERIALS , 2024 , 465 . |
| MLA | Ma, Yujie et al. "Efficient magnetic enrichment cascade single-step RPA-CRISPR/Cas12a assay for rapid and ultrasensitive detection of Staphylococcus aureus in food samples" . | JOURNAL OF HAZARDOUS MATERIALS 465 (2024) . |
| APA | Ma, Yujie , Wei, Hongjuan , Wang, Yunxiang , Cheng, Xiaodan , Chen, Hong , Yang, Xingsheng et al. Efficient magnetic enrichment cascade single-step RPA-CRISPR/Cas12a assay for rapid and ultrasensitive detection of Staphylococcus aureus in food samples . | JOURNAL OF HAZARDOUS MATERIALS , 2024 , 465 . |
| 导入链接 | NoteExpress RIS BibTex |
摘要 ：
Despite recent advances have been made in clinical treatments of breast cancer, the general prognosis of patients remains poor. Therefore, it is imperative to develop a more effective therapeutic strategy. Lysine demethylase 4B (KDM4B) has been reported to participate in breast cancer development recently, but its exact biological role in breast cancer remains unclear. Here, we observed that KDM4B was down-regulated in human primary BRCA tissues and the low levels of KDM4B expression were correlated with poor survival. Gain- and loss-of-function experiments showed that KDM4B inhibited the proliferation and metastasis of breast cancer cells. Besides, knockdown of KDM4B promoted the epithelial-mesenchymal transition (EMT) and cell stemness in breast cancer cells. Mechanistically, KDM4B down-regulates PHGDH by decreasing the enrichment of H3K36me3 on the promoter region of PHGDH. Knockdown of PHGDH could significantly reversed proliferation, migration, EMT, and cell stemness induced by KDM4B silencing in breast cancer cells. Collectively, we propose a model for a KDM4B/PHGDH axis that provides novel insight into breast cancer development, which may serve as a potential factor for predicting prognosis and a therapeutic target for breast cancer.
关键词 ：
KDM4B KDM4B Breast cancer Breast cancer PHGDH PHGDH Stemness Stemness
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| GB/T 7714 | Wang, Xin-Yu , Li, Hong-Ming , Xia, Ran et al. KDM4B down-regulation facilitated breast cancer cell stemness via PHGDH upregulation in H3K36me3-dependent manner [J]. | MOLECULAR AND CELLULAR BIOCHEMISTRY , 2023 , 479 (4) : 915-928 . |
| MLA | Wang, Xin-Yu et al. "KDM4B down-regulation facilitated breast cancer cell stemness via PHGDH upregulation in H3K36me3-dependent manner" . | MOLECULAR AND CELLULAR BIOCHEMISTRY 479 . 4 (2023) : 915-928 . |
| APA | Wang, Xin-Yu , Li, Hong-Ming , Xia, Ran , Li, Xiang , Zhang, Xing , Jin, Tong-Zhao et al. KDM4B down-regulation facilitated breast cancer cell stemness via PHGDH upregulation in H3K36me3-dependent manner . | MOLECULAR AND CELLULAR BIOCHEMISTRY , 2023 , 479 (4) , 915-928 . |
| 导入链接 | NoteExpress RIS BibTex |
摘要 ：
Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death and has been implicated in the occurrence and development of various diseases, including heart disease, nervous system diseases and cancer. Ferroptosis induction recently emerged as an attractive strategy for cancer therapy. Ferroptosis has become a potential target for intervention in these diseases or injuries in relevant preclinical models. This review summarizes recent progress on the mechanisms of ferroptosis resistance in cancer, highlights redox status and metabolism's role in it. Combination therapy for ferroptosis has great potential in cancer treatment, especially malignant tumors that are resistant to conventional therapies. This review will lead us to have a comprehensive understanding of the future exploration of ferroptosis and cancer therapy. A deeper understanding of the relationship between ferroptosis resistance and metabolism reprogramming may provide new strategies for tumor treatment and drug development based on ferroptosis.
关键词 ：
Ferroptosis resistance Ferroptosis resistance Ferroptosis Ferroptosis Programmed cell death Programmed cell death Cancer therapies Cancer therapies Metabolism Metabolism
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| GB/T 7714 | Zhang, Xing , Li, Xiang , Xia, Ran et al. Ferroptosis resistance in cancer: recent advances and future perspectives [J]. | BIOCHEMICAL PHARMACOLOGY , 2023 , 219 . |
| MLA | Zhang, Xing et al. "Ferroptosis resistance in cancer: recent advances and future perspectives" . | BIOCHEMICAL PHARMACOLOGY 219 (2023) . |
| APA | Zhang, Xing , Li, Xiang , Xia, Ran , Zhang, Hong-Sheng . Ferroptosis resistance in cancer: recent advances and future perspectives . | BIOCHEMICAL PHARMACOLOGY , 2023 , 219 . |
| 导入链接 | NoteExpress RIS BibTex |
摘要 ：
药理学线上线下混合式教学的思考与实践
关键词 ：
线上线下混合式教学 线上线下混合式教学 慕课 慕课 课程思政 课程思政 药理学 药理学
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| GB/T 7714 | 张红胜 , 科技资讯 . 药理学线上线下混合式教学的思考与实践 [J]. | 张红胜 , 2021 , 19 (5) : 155-158 . |
| MLA | 张红胜 et al. "药理学线上线下混合式教学的思考与实践" . | 张红胜 19 . 5 (2021) : 155-158 . |
| APA | 张红胜 , 科技资讯 . 药理学线上线下混合式教学的思考与实践 . | 张红胜 , 2021 , 19 (5) , 155-158 . |
| 导入链接 | NoteExpress RIS BibTex |
摘要 ：
如何充分发掘药理学专业基础课程所蕴含的课程思政元素,将其融入日常教学,对实现三全育人,引导当代大学生建立正确人生观、价值观及职业观,具有重要的现实意义.本文主要从探索课程思政与药理学专业课程的有效融合教学范式,发挥立德树人和三全育人的重要作用.
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| GB/T 7714 | 张红胜 . 学科历史与学科前沿融入药理学课程思政的探索与实践 [J]. | 产业与科技论坛 , 2021 , 20 (10) : 153-154 . |
| MLA | 张红胜 . "学科历史与学科前沿融入药理学课程思政的探索与实践" . | 产业与科技论坛 20 . 10 (2021) : 153-154 . |
| APA | 张红胜 . 学科历史与学科前沿融入药理学课程思政的探索与实践 . | 产业与科技论坛 , 2021 , 20 (10) , 153-154 . |
| 导入链接 | NoteExpress RIS BibTex |
摘要 ：
课程思政是新时期高校教育新模式.如何充分发掘医学基础专业基础课程蕴含的课程思政元素,将其融入教学实践过程中,对实现三全育人,引导学生建立正确的人生观、价值观及职业观,具有重要的现实意义.通过对医学基础的课程思政元素和教案设计进行探索与实践,设计医学基础课程思政的切入点、思路.通过教学实践与教学反思,准确地把握思想政治教育的时机与方法.主要探索课程思政与医学基础课程的有效融合教学范式,发挥立德树人和三全育人的重要作用.
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| GB/T 7714 | 张红胜 , 王明连 . 研究生医学基础课程思政教学的探索与实践 [J]. | 教育教学论坛 , 2021 , (38) : 58-61 . |
| MLA | 张红胜 et al. "研究生医学基础课程思政教学的探索与实践" . | 教育教学论坛 38 (2021) : 58-61 . |
| APA | 张红胜 , 王明连 . 研究生医学基础课程思政教学的探索与实践 . | 教育教学论坛 , 2021 , (38) , 58-61 . |
| 导入链接 | NoteExpress RIS BibTex |
摘要 ：
Cancer cells can metabolize glutamine to replenish TCA cycle intermediates for cell survival. Glutaminase (GLS1) is over-expressed in multiple cancers, including colorectal cancer (CRC). However, the role of GLS1 in colorectal cancer development has not yet fully elucidated. In this study, we found that GLS1 levels were significantly increased in CRC cells. Knockdown of GLS1 by shRNAs as well as GLS1 inhibitor BPTES decreased DLD1 and SW480 cell proliferation, colony formation and migration. Knockdown of GLS1 as well as BPTES induced reactive oxygen species (ROS) production, down-regulation of GSH/GSSG ratio, an decrease in Nrf2 protein expression and an increase in cytoplasmic Nrf2 protein expression in DLD1 and SW480 cells. Furthermore, Knockdown of GLS1 as well as BPTES inhibited autophagy pathway, antioxidant NAC and Nrf2 activator could reversed inhibition of GLS1-mediated an decrease in autophagic flux in DLD1 and SW480 cells. Depletion of GLS1-induced inhibition of DLD1 and SW480 CRC cell proliferation, colony formation and migration was reversed by autophagy inducer rapamycin. These results suggest that targeting GLS1 might be a new potential therapeutic target for the treatment of CRC.
关键词 ：
GLS1 GLS1 Redox Redox Autophagy Autophagy Colorectal cancer Colorectal cancer
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| GB/T 7714 | Liu, Hui-Yun , Zhang, Hong-Sheng , Liu, Min-Yao et al. GLS1 depletion inhibited colorectal cancer proliferation and migration via redox/Nrf2/autophagy-dependent pathway [J]. | ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS , 2021 , 708 . |
| MLA | Liu, Hui-Yun et al. "GLS1 depletion inhibited colorectal cancer proliferation and migration via redox/Nrf2/autophagy-dependent pathway" . | ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 708 (2021) . |
| APA | Liu, Hui-Yun , Zhang, Hong-Sheng , Liu, Min-Yao , Li, Hong-Ming , Wang, Xin-Yu , Wang, Miao . GLS1 depletion inhibited colorectal cancer proliferation and migration via redox/Nrf2/autophagy-dependent pathway . | ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS , 2021 , 708 . |
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摘要 ：
Road datasets are fundamental and imperative for traffic management and urban planning. Different high resolution optical remote sensing images are widely used for automatic road extraction but the results are usually limited to local scale and spectral confusions in barren and cropland, while accurate large-scale road extraction remains challenging. In this study, we incorporated medium resolution optical and SAR data, i.e., 10 meter resolution Sentinel-1 and Sentinel-2, for road extraction at a large scale and evaluated the contribution of different data sources. We developed a United U-Net (UU-Net) to fuse optical and SAR data for road extraction, which was trained and evaluated on a large-scale multisource road extraction dataset. The UU-Net achieved better accuracy than traditional deep convolutional networks with optical or SAR data alone, which obtained an average F1 of 0.5502 and an average IoU of 0.4021, outperforming in 160 out of 200 (80%) 0.5-by-0.5 degree evaluation grids. The results indicated that SAR contributes more to road extraction in barren land, while optical data contributes more to large slope areas. The road accuracy is positively related to elevation and urban percentage, which distributes higher in eastern China and lower in western. The road centerline from 10 m road showed comparable results with that from Open Street Map (OSM), indicating its promising applications to support large-scale urban transportation studies.
关键词 ：
U-Net U-Net SAR SAR OSM OSM Road Road Optical Optical
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| GB/T 7714 | Lin, Yinyi , Wan, Luoma , Zhang, Hongsheng et al. Leveraging optical and SAR data with a UU-Net for large-scale road extraction [J]. | INTERNATIONAL JOURNAL OF APPLIED EARTH OBSERVATION AND GEOINFORMATION , 2021 , 103 . |
| MLA | Lin, Yinyi et al. "Leveraging optical and SAR data with a UU-Net for large-scale road extraction" . | INTERNATIONAL JOURNAL OF APPLIED EARTH OBSERVATION AND GEOINFORMATION 103 (2021) . |
| APA | Lin, Yinyi , Wan, Luoma , Zhang, Hongsheng , Wei, Shan , Ma, Peifeng , Li, Yu et al. Leveraging optical and SAR data with a UU-Net for large-scale road extraction . | INTERNATIONAL JOURNAL OF APPLIED EARTH OBSERVATION AND GEOINFORMATION , 2021 , 103 . |
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