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学者姓名：乔爱科
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摘要 ：
Tracheal stents can be used to quickly reconstruct the airway and relieve symptoms of dyspnea in patients with tracheal stenosis. However, existing tracheal stents lead to complications such as granulation tissue formation, difficulty in removal, persistent growth of malignant tumors, stent migration, and mucus plugging. In this article, we reviewed the main methods used to reduce complications associated with tracheal stent design. Drug-eluting stents can inhibit granulation tissue formation and prevent infection and local chemotherapy. The biodegradable stent can support the trachea for some time, maintain tracheal patency, and degrade gradually, which avoids removing or replacing the stent. Radioactive stents loaded with I-125 have good potential for inhibiting the persistent growth of malignant tumors. Three-dimensional printing technology enables the manufacturing of patient-specific stents, which increases the degree of matching between the complex tracheal anatomy and the stent, thus providing a new solution for stent migration caused by structural mismatch. Minimizing the barrier of the stent to mucociliary clearance, providing an anti-fouling coating, and culturing respiratory epithelial cells on the surface of the stent are the main methods used to reduce mucus plugging. We also proposed future research directions for tracheal stents to guide the design and manufacture of ideal tracheal stents.
关键词 ：
Tracheal stent Tracheal stent Granulation tissue formation Granulation tissue formation Stent migration Stent migration Mucus plugging Mucus plugging
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| GB/T 7714 | Chen, Shiliang , Du, Tianming , Zhang, Hanbing et al. Advances in studies on tracheal stent design addressing the related complications [J]. | MATERIALS TODAY BIO , 2024 , 29 . |
| MLA | Chen, Shiliang et al. "Advances in studies on tracheal stent design addressing the related complications" . | MATERIALS TODAY BIO 29 (2024) . |
| APA | Chen, Shiliang , Du, Tianming , Zhang, Hanbing , Zhang, Yanping , Qiao, Aike . Advances in studies on tracheal stent design addressing the related complications . | MATERIALS TODAY BIO , 2024 , 29 . |
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摘要 ：
Mineralized collagen scaffold is one of the best choices for bone defects treatment, but weak mechanical strength is the main factor restricting its development. Recent studies demonstrated that despite being a fundamental form of mechanical stimulation in human activities, the impact of cyclic compressive stress on collagen mineralization remains unclear, with even less known about the dynamic mechanical mechanism. This study employed cyclic compressive stress to investigate its effect on collagen mineralization. The findings revealed that cyclic compressive strain promotes collagen mineralization by facilitating increased mineral penetration into the collagen and altering mineral morphology on the collagen surface. As the mineral volume fraction of mineralized collagen rises, its elastic modulus also increases. Additionally, the finite element simulation results proved that cyclic compressive stress can impact mineral distribution by affecting their transport and deposition, consequently influencing the stress distribution and regulating mechanical properties of mineralized collagen. Alterations in mechanical properties provide feedback on internal stress distribution, subsequently impacting mineral mineralization. This study achieves a closed-loop study on the mechanical regulated collagen mineralization, offers insight into the mechanism of collagen mineralization, paving the way for further exploration of biomineralization mechanisms and potentially inspiring novel approaches for the fabrication of mineralized collagen scaffolds.
关键词 ：
Mechanical property Mechanical property Mechano-regulatory Mechano-regulatory Biomineralization Biomineralization Multi -morphology Multi -morphology Stress distribution Stress distribution Multiscale modelling Multiscale modelling
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| GB/T 7714 | Niu, Yumiao , Chen, Jiawen , Geng, Ziyao et al. Compressive stress improves mechanical properties of mineralized collagen by dynamically regulating its mineralization - a closed-loop regulation mechanism [J]. | MATERIALS & DESIGN , 2024 , 239 . |
| MLA | Niu, Yumiao et al. "Compressive stress improves mechanical properties of mineralized collagen by dynamically regulating its mineralization - a closed-loop regulation mechanism" . | MATERIALS & DESIGN 239 (2024) . |
| APA | Niu, Yumiao , Chen, Jiawen , Geng, Ziyao , Wu, Wei , Cai, Hefang , Liu, Chenxin et al. Compressive stress improves mechanical properties of mineralized collagen by dynamically regulating its mineralization - a closed-loop regulation mechanism . | MATERIALS & DESIGN , 2024 , 239 . |
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摘要 ：
本发明公开了一种磷酸盐介导的矿化胶原及其自组装方法和应用，具体涉及生物医用材料技术领域。所述方法包括在弱碱性条件下，利用可溶性多聚磷酸盐改性胶原纤维，得改性胶原纤维溶液；再在改性胶原纤维溶液中加入钙盐继续反应，得初始胶原纤维溶液；接着在初始胶原纤维溶液中加入碱性磷酸酶，控制pH，利用碱性磷酸酶调控胶原纤维的矿化，得矿化骨基质溶液；最后矿化骨基质溶液经清洗、离心、浓缩和冷冻干燥得磷酸盐介导的矿化胶原。本发明充分考虑了离子来源、化学反应平衡及化学因素添加顺序在矿化中的影响，构建了多因素协同调控体系，更好的模拟了体内复杂的骨基质矿化组装过程。
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| GB/T 7714 | 杜田明 , 乔爱科 , 杨海胜 et al. 一种磷酸盐介导的矿化胶原及其自组装方法和应用 : CN202310744975.4[P]. | 2023-06-21 . |
| MLA | 杜田明 et al. "一种磷酸盐介导的矿化胶原及其自组装方法和应用" : CN202310744975.4. | 2023-06-21 . |
| APA | 杜田明 , 乔爱科 , 杨海胜 , 刘有军 . 一种磷酸盐介导的矿化胶原及其自组装方法和应用 : CN202310744975.4. | 2023-06-21 . |
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摘要 ：
Bone mineralization involves the deposition of inorganic on organic matter and the regulation of non - collagenous proteins expressed by functional cells in bone tissue, is a fundamental process during skeletal growth, remodeling, and regeneration. Metal elements are the main constitutive elements of bone minerals. It is worth noting that the distribution and effects of metal elements depend on their type and content throughout the body, suggesting that different metal elements can regulate bone mineralization in different ways. Various metal elements can directly modify calcium phosphate (Ca-phosphate) formation in the bone matrix through ion exchanging, coating, and doping. Additionally, metal elements regulate bone mineralization by targeting important signaling pathways, protein secretion, and the expression of genes involved in the proliferation, dif- ferentiation and migration of cells involved in bone. This review introduces the roles of metal elements commonly found in nature bone. It summarizes recent studies on the prominent role of Ca element, special roles of divalent metal elements, trivalent metal elements, metal elements with various valences, and new points of heavy metal elements in bone mineralization. We also discuss potential future research directions on the roles of metal/non-metal elements and their interactions in bone mineralization, offering the basis for future in- vestigations for the development of advanced bone substitute materials and orthopedic implants.
关键词 ：
Metal element Metal element Mineralization Mineralization Bone regeneration Bone regeneration Regulation Regulation
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| GB/T 7714 | Du, Tianming , Niu, Xufeng , Cao, Peng et al. Multifarious roles of metal elements in bone mineralization [J]. | APPLIED MATERIALS TODAY , 2023 , 32 . |
| MLA | Du, Tianming et al. "Multifarious roles of metal elements in bone mineralization" . | APPLIED MATERIALS TODAY 32 (2023) . |
| APA | Du, Tianming , Niu, Xufeng , Cao, Peng , Zhang, Yanping , Liu, Youjun , Yang, Haisheng et al. Multifarious roles of metal elements in bone mineralization . | APPLIED MATERIALS TODAY , 2023 , 32 . |
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摘要 ：
Boundary condition settings are key risk factors for the accuracy of noninvasive quantification of fractional flow reserve (FFR) based on computed tomography angiography (i.e., FFRCT). However, transient numerical simulation-based FFRCT often ignores the three-dimensional (3D) model of coronary artery and clinical statistics of hyperemia state set by boundary conditions, resulting in insufficient computational accuracy and high computational cost. Therefore, it is necessary to develop the custom function that combines the 3D model of the coronary artery and clinical statistics of hyperemia state for boundary condition setting, to accurately and quickly quantify FFRCT under steady-state numerical simulations. The 3D model of the coronary artery was reconstructed by patient computed tomography angiography (CTA), and coronary resting flow was determined from the volume and diameter of the 3D model. Then, we developed the custom function that took into account the interaction of stenotic resistance, microcirculation resistance, inlet aortic pressure, and clinical statistics of resting to hyperemia state due to the effect of adenosine on boundary condition settings, to accurately and rapidly identify coronary blood flow for quantification of FFRCT calculation (FFRU). We tested the diagnostic accuracy of FFRU calculation by comparing it with the existing methods (CTA, coronary angiography (QCA), and diameter-flow method for calculating FFR (FFRD)) based on invasive FFR of 86 vessels in 73 patients. The average computational time for FFRU calculation was greatly reduced from 1-4 h for transient numerical simulations to 5 min per simulation, which was 2-fold less than the FFRD method. According to the results of the Bland-Altman analysis, the consistency between FFRU and invasive FFR of 86 vessels was better than that of FFRD. The area under the receiver operating characteristic curve (AUC) for CTA, QCA, FFRD and FFRU at the lesion level were 0.62 (95% CI: 0.51-0.74), 0.67 (95% CI: 0.56-0.79), 0.85 (95% CI: 0.76-0.94), and 0.93 (95% CI: 0.87-0.98), respectively. At the patient level, the AUC was 0.61 (95% CI: 0.48-0.74) for CTA, 0.65 (95% CI: 0.53-0.77) for QCA, 0.83 (95% CI: 0.74-0.92) for FFRD, and 0.92 (95% CI: 0.89-0.96) for FFRU. The proposed novel method might accurately and rapidly identify coronary blood flow, significantly improve the accuracy of FFRCT calculation, and support its wide application as a diagnostic indicator in clinical practice.
关键词 ：
boundary condition setting boundary condition setting fractional flow reserve fractional flow reserve steady-state numerical simulations steady-state numerical simulations noninvasive quantification noninvasive quantification custom function custom function
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| GB/T 7714 | Zhang, Honghui , Song, Xiaorui , Wu, Rile et al. A novel method for noninvasive quantification of fractional flow reserve based on the custom function [J]. | FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY , 2023 , 11 . |
| MLA | Zhang, Honghui et al. "A novel method for noninvasive quantification of fractional flow reserve based on the custom function" . | FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 11 (2023) . |
| APA | Zhang, Honghui , Song, Xiaorui , Wu, Rile , Li, Na , Hou, Qianwen , Xie, Jinjie et al. A novel method for noninvasive quantification of fractional flow reserve based on the custom function . | FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY , 2023 , 11 . |
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摘要 ：
ObjectiveHemodynamics-induced low wall shear stress (WSS) is one of the critical reasons leading to vascular remodeling. However, the coupling effects of WSS and cellular kinetics have not been clearly modeled. The aim of this study was to establish a multiscale modeling approach to reveal the vascular remodeling behavior under the interaction between the macroscale of WSS loading and the microscale of cell evolution. MethodsComputational fluid dynamics (CFD) method and agent-based model (ABM), which have significantly different characteristics in temporal and spatial scales, were adopted to establish the multiscale model. The CFD method is for the second/organ scale, and the ABM is for the month/cell scale. The CFD method was used to simulate blood flow in a vessel and obtain the WSS in a vessel cross-section. The simulations of the smooth muscle cell (SMC) proliferation/apoptosis and extracellular matrix (ECM) generation/degradation in a vessel cross-section were performed by using ABM. During the simulation of the vascular remodeling procedure, the damage index of the SMC and ECM was defined as deviation from the obtained WSS. The damage index decreased gradually to mimic the recovery of WSS-induced vessel damage. Results(1) The significant wall thickening region was consistent with the low WSS region. (2) There was no evident change of wall thickness in the normal WSS region. (3) When the damage index approached to 0, the amount and distribution of SMCs and ECM achieved a stable state, and the vessel reached vascular homeostasis. ConclusionThe established multiscale model can be used to simulate the vascular remodeling behavior over time under various WSS conditions.
关键词 ：
multiscale modeling multiscale modeling wall shear stress wall shear stress vascular remodeling vascular remodeling agent-based model agent-based model computational fluid dynamics computational fluid dynamics
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| GB/T 7714 | Chen, Shiliang , Zhang, Hanbing , Hou, Qianwen et al. Multiscale Modeling of Vascular Remodeling Induced by Wall Shear Stress [J]. | FRONTIERS IN PHYSIOLOGY , 2022 , 12 . |
| MLA | Chen, Shiliang et al. "Multiscale Modeling of Vascular Remodeling Induced by Wall Shear Stress" . | FRONTIERS IN PHYSIOLOGY 12 (2022) . |
| APA | Chen, Shiliang , Zhang, Hanbing , Hou, Qianwen , Zhang, Yu , Qiao, Aike . Multiscale Modeling of Vascular Remodeling Induced by Wall Shear Stress . | FRONTIERS IN PHYSIOLOGY , 2022 , 12 . |
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摘要 ：
Percutaneous coronary intervention with stent implantation is one of the most commonly used approaches to treat coronary artery stenosis. Stent malapposition (SM) can increase the incidence of stent thrombosis, but the quantitative association between SM distance and stent thrombosis is poorly clarified. The objective of this study is to determine the biomechanical reaction mechanisms underlying stent thrombosis induced by SM and to quantify the effect of different SM severity grades on thrombosis. The thrombus simulation was performed in a continuous model based on the diffusion-convection response of blood substance transport. Simulated models included well-apposed stents and malapposed stents with various severities where the detachment distances ranged from 0 to 400 mu m. The abnormal shear stress induced by SM was considered a critical contributor affecting stent thrombosis, which was dependent on changing SM distances in the simulation. The results illustrate that the proportion of thrombus volume was 1.88% at a SM distance of 75 mu m (mild), 3.46% at 150 mu m, and 3.93% at 400 mu m (severe), but that a slight drop (3.18%) appeared at the detachment distance of 225 mu m (intermediate). The results indicate that when the SM distance was less than 150 mu m, the thrombus rose notably as the gap distance increased, whereas the progression of thrombogenicity weakened when it exceeded 150 mu m. Therefore, more attention should be paid when SM is present at a gap distance of 150 mu m. Moreover, when the SM length of stents are the same, thrombus tends to accumulate downstream towards the distal end of the stent as the SM distance increases.
关键词 ：
stent malapposition stent malapposition dynamic thrombus formation dynamic thrombus formation shear-induced thrombus aggregation shear-induced thrombus aggregation computational fluid dynamics computational fluid dynamics 3D continuum model 3D continuum model stent thrombosis stent thrombosis
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| GB/T 7714 | Qu, Zhuoran , Wei, Hongge , Du, Tianming et al. Computational simulation of stent thrombosis induced by various degrees of stent malapposition [J]. | FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY , 2022 , 10 . |
| MLA | Qu, Zhuoran et al. "Computational simulation of stent thrombosis induced by various degrees of stent malapposition" . | FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 10 (2022) . |
| APA | Qu, Zhuoran , Wei, Hongge , Du, Tianming , Qiao, Aike . Computational simulation of stent thrombosis induced by various degrees of stent malapposition . | FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY , 2022 , 10 . |
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摘要 ：
Most of the studies on the finite element analysis (FEA) of biodegradable vascular stents (BVSs) during the degradation process have limited the accuracy of the simulation results due to the application of the uniform degradation model. This paper aims to establish an FEA model for the non-uniform degradation of BVSs by considering factors such as the dynamic changes of the corrosion properties and material properties of the element, as well as the pitting corrosion and stress corrosion. The results revealed that adjusting the corrosion rate according to the number of exposed surfaces of the element and reducing the stress threshold according to the corrosion status accelerates the degradation time of BVSs by 26% and 25%, respectively, compared with the uniform degradation model. The addition of the pitting model reduces the service life of the BVSs by up to 12%. The effective support of the stent to the vessel could reach at least 60% of the treatment effect before the vessel collapsed. These data indicate that the proposed non-uniform degradation model of BVSs with multiple factors produces different phenomena compared with the commonly used models and make the numerical simulation results more consistent with the real degradation scenario.
关键词 ：
biodegradable vascular stents biodegradable vascular stents non-uniform degradation non-uniform degradation continuum damage mechanics continuum damage mechanics finite element method finite element method
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| GB/T 7714 | Zhang, Hanbing , Du, Tianming , Chen, Shiliang et al. Finite Element Analysis of the Non-Uniform Degradation of Biodegradable Vascular Stents [J]. | JOURNAL OF FUNCTIONAL BIOMATERIALS , 2022 , 13 (3) . |
| MLA | Zhang, Hanbing et al. "Finite Element Analysis of the Non-Uniform Degradation of Biodegradable Vascular Stents" . | JOURNAL OF FUNCTIONAL BIOMATERIALS 13 . 3 (2022) . |
| APA | Zhang, Hanbing , Du, Tianming , Chen, Shiliang , Liu, Yang , Yang, Yujia , Hou, Qianwen et al. Finite Element Analysis of the Non-Uniform Degradation of Biodegradable Vascular Stents . | JOURNAL OF FUNCTIONAL BIOMATERIALS , 2022 , 13 (3) . |
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摘要 ：
Background and objectives: The bicuspid aortic valve (BAV) is a major risk factor for the progression of aortic dilation (AD) because of the induced abnormal blood flow environment in aorta. The differences in the development of AD induced by BAV phenotypes remains unclear. Therefore, the objective of this study was to assess the potential locations of AD induced by different phenotypes of BAV. The different effects of opening orifice area and leaflet orientation on ascending aortic hemodynamics in Type-1 BAV was investigated by means of numerical simulation.Methods: Finite element dynamic analysis was performed on tricuspid aortic valve (TAV) and BAV models to simulate the motion of the leaflets and obtain the geometrical characteristics of AV at peak systole as a reference, which were used for aortic models. Then, four sets of aortic fluid models were designed according to the leaflet fusion types [TAV; BAV (left-right-coronary cusp fusion, LR; right-non-coronary cusp fusion, RN; left-non-coronary cusp fusion, LN)], and the computational fluid dynamics method was applied to compare the hemodynamic differences within the aorta at peak systole. Results: The maximum opening area of BAV was significantly reduced, resulting in alterations in aortic hemodynamics compared with TAV. The velocity streamlines were essentially parallel to the aortic wall in TAV. The average pressure and wall shear stress in aorta tend to be stable. In contrary, the eccentricity of BAV orifice jet resulted in high-velocity flow directed toward the ascending aorta (AA) wall and aortic arch for LR and LN; RN features an asymmetrical velocity distribution toward the outer bend of the middle AA, and eccentric flow tends to impact the distal AA. As the flow angle is associated with distinct flow impingement locations, different degrees of WSS and pressure concentration occur along the aortic wall from the AA to the aortic arch in three BAV types.Conclusions: The BAV morphotype affects the aortic hemodynamics, and the abnormal blood flow associated with BAV may play a role in AD. The different BAV phenotypes determine the direction of blood flow jet and change the expression of dilation. LR is likely to cause dilation of the tubular AA; RN results in dilation of the middle AA to proximal aortic arch; and LN causes an increased incidence of the tubular AA and the proximal aortic arch.(c) 2022 Elsevier B.V. All rights reserved.
关键词 ：
Hemodynamics Hemodynamics Numerical simulation Numerical simulation Aortic dilation Aortic dilation Peak systolic period Peak systolic period Bicuspid aortic valve Bicuspid aortic valve
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| GB/T 7714 | Hou, Qianwen , Tao, Keyi , Du, Tianming et al. A computational analysis of potential aortic dilation induced by the hemodynamic effects of bicuspid aortic valve phenotypes [J]. | COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE , 2022 , 220 . |
| MLA | Hou, Qianwen et al. "A computational analysis of potential aortic dilation induced by the hemodynamic effects of bicuspid aortic valve phenotypes" . | COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE 220 (2022) . |
| APA | Hou, Qianwen , Tao, Keyi , Du, Tianming , Wei, Hongge , Zhang, Honghui , Chen, Shiliang et al. A computational analysis of potential aortic dilation induced by the hemodynamic effects of bicuspid aortic valve phenotypes . | COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE , 2022 , 220 . |
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摘要 ：
目的血管内异常血流动力学尤其低壁面切应力的作用是诱导血管重建的原因之一。探讨如何建立低壁面切应力诱导血管重建的多尺度模型,模拟血管重建的动态变化过程,进而阐释低壁面切应力诱导血管重建随时间变化的规律。方法在宏观尺度,利用计算流体动力学方法模拟腹主动脉血液流动,获得指定腹主动脉横截面的壁面切应力结果。在微观尺度,采用基于代理模型方法建立该横截面的血管重建模型,并将其壁面切应力作为输入条件,
关键词 ：
平滑肌细胞 平滑肌细胞 多尺度模拟 多尺度模拟 正性重构 正性重构 细胞外基质 细胞外基质 壁面切应力 壁面切应力
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| GB/T 7714 | 陈诗亮 , 乔爱科 . 壁面切应力诱导血管重建的多尺度模拟 [J]. | 医用生物力学 , 2021 , 36 (S1) : 52 . |
| MLA | 陈诗亮 et al. "壁面切应力诱导血管重建的多尺度模拟" . | 医用生物力学 36 . S1 (2021) : 52 . |
| APA | 陈诗亮 , 乔爱科 . 壁面切应力诱导血管重建的多尺度模拟 . | 医用生物力学 , 2021 , 36 (S1) , 52 . |
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